BOOST cells
Sponsors
Karolinska Institutet, Christian Medical College, Vellore, India
Conditions
Osteogenesis ImperfectaOsteogenesis Imperfecta (OI) type III and severe type IV.
Severe type of congenital Brittle bone disease.
Phase 1
Boost Brittle Bones Before Birth
Active, not recruitingNCT03706482
Start: 2019-08-12End: 2030-04-30Updated: 2025-09-12
Boost to Brittle Bones - Stem Cell Transplantation for Treatment of Brittle Bones
NCT04623606
Start: 2019-05-20End: 2021-12-31Target: 15Updated: 2020-11-10
An exploratory, open label, multiple dose, multicentre phase I/II trial evaluating safety and efficacy of postnatal or prenatal and postnatal intravenous administration of allogeneic expanded fetal mesenchymal stem cells for the treatment of severe Osteogenesis Imperfecta compared with a combination of historical and untreated prospective controls.
Active, not recruitingCTIS2023-504593-38-00
Start: 2019-08-12Target: 138Updated: 2024-09-02