BLINCYTO 38.5 micrograms powder for concentrate and solution for solution for infusion.
Sponsors
Cardiff University, Charite Universitaetsmedizin Berlin KöR, Universitaetsklinikum Schleswig-Holstein, Assistance Publique Hopitaux De Paris, St. Anna Childrens Cancer Research Institute GmbH
Conditions
Acute Lymphoblastic LeukaemiaAcute lymphoblastic leukemia (ALL)Blood cancerGranulomatous PolyangiitisPatients aged 18-65 years old with newly diagnosed previously untreated ALL or T-LL.Ph/BCR::ABL1 positive (Ph+)Philadelphia Chromosome Positive or ABL-class Philadelphia Chromosome-Like B-cell Acute Lymphoblastic LeukemiaRelapsed Acute Lymphoblastic Leukemia (ALL)
Phase 1
Phase 2
ALL SCTped 2012 FORUM - Allogeneic Stem Cell Transplantation in Children and Adolescents with Acute Lymphoblastic Leukaemia
RecruitingCTIS2024-512657-24-00
Start: 2014-03-27Target: 1108Updated: 2025-11-18
GRAALL 2024 - A 3-cohort Randomized Study evaluating the role of New Immunotherapeutic Agents and of Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) in Frontline Therapy of Adults with Acute Lymphoblastic Leukemia
RecruitingCTIS2024-511437-35-00
Start: 2026-01-05Target: 1100Updated: 2025-11-20
A multicentre, randomized trial in adults with de novo Philadelphia-Chromosome positive acute lymphoblastic leukemia to assess the efficacy of ponatinib versus imatinib in combination with low-intensity chemotherapy, to compare end of therapy with indication for SCT versus TKI, blinatumomab and chemotherapy in optimal responders and to evaluate blinatumomab in suboptimal responders (GMALL-EVOLVE)
RecruitingCTIS2024-517966-40-00
Start: 2023-07-13Target: 208Updated: 2026-01-08
EWALL-PH-03: An open label, 2-arm, Randomised phase II study to Compare the Safety and Efficacy of Ponatinib plus Chemotherapy with Imatinib plus Chemotherapy as front-line therapy for patients aged 55 years and over with Philadelphia chromosome positive (Ph+ or BCR-ABL+) Acute Lymphoblastic Leukemia (ALL)
Not yet recruitingCTIS2023-505330-95-01
Target: 100Updated: 2025-10-08
A Phase II, Open-Label, Single-Center, Single-Arm Pilot Study to Evaluate the Safety, Tolerability and Efficacy of Blinatumomab for Treatment of Patients with Autoimmune B-Cell driven Diseases including Systemic Lupus Erythematosus (SLE), Systemic Sclerosis (SSc) and Granulomatous Polyangiitis (GPA)
RecruitingCTIS2025-523061-22-00
Start: 2025-11-14Target: 5Updated: 2025-11-18
Phase 3
AIEOP-BFM ALL 2017 - International collaborative treatment protocol for children and adolescents with acute lymphoblastic leukemia
Active, not recruitingCTIS2023-509856-32-00
Start: 2018-07-15Target: 4250Updated: 2025-08-19
International Study for Treatment of Childhood Relapsed Precursor B-Cell ALL 2020 - A Randomized Phase III Study Conducted by the Resistant Disease Committee of the International BFM Study Group - IntReALL BCP 2020
Not yet recruitingCTIS2023-509392-17-00
Target: 765Updated: 2025-12-15
AALL2131/EsPhALL2022, An International Pilot Study of Chemotherapy and Tyrosine Kinase Inhibitor with Blinatumomab in Patients with Newly Diagnosed Philadelphia Chromosome Positive or ABL-class Philadelphia Chromosome-Like B-cell Acute Lymphoblastic Leukemia
Not yet recruitingCTIS2025-520982-39-00
Target: 87Updated: 2025-12-15