BIIB074

DRUG12 trials

Conditions

Diabetes MellitusDiabetic NeuropathiesDrug InteractionDrug InteractionsHealthyHealthy VolunteersLumbosacral RadiculopathyNeuropathic Pain

Phase 1

Effect of Itraconazole on the Pharmacokinetics of BIIB074

CompletedNCT02698267

BiogenNeuropathic Pain

Start: 2016-02-29End: 2016-04-30Updated: 2016-06-09

Absorption, Metabolism, and Excretion Study of BIIB074

CompletedNCT02751905

BiogenNeuropathic Pain

Start: 2016-04-30End: 2016-05-31Updated: 2016-06-16

PK and Safety Study of BIIB074 in Healthy Japanese and Caucasian Participants

CompletedNCT02831517

BiogenHealthy, Trigeminal Neuralgia

Start: 2016-08-31End: 2017-02-28Updated: 2017-03-09

A Drug Interaction Study of BIIB074 and an Oral Contraceptive Regimen

CompletedNCT03324685

BiogenDrug Interactions

Start: 2017-11-11End: 2018-03-15Updated: 2018-09-25

Study to Evaluate the Effect of UGT Inhibition by Valproic Acid on the Pharmacokinetics of BIIB074

CompletedNCT03385525

BiogenDrug Interaction

Start: 2017-09-12End: 2017-10-13Updated: 2018-04-20

Pharmacodynamic Study of BIIB095 and BIIB074 in Healthy Participants and Participants With Painful Diabetic Polyneuropathy

WithdrawnNCT04106050

BiogenDiabetic Neuropathies, Healthy Volunteers

Start: 2020-09-30End: 2022-01-21Updated: 2021-03-22

Phase 2

A Phase 2a Study of BIIB074 in the Treatment of Erythromelalgia

CompletedNCT02917187

BiogenPrimary Inherited Erythromelalgia

Start: 2016-09-09End: 2017-01-05Updated: 2018-01-10

Study to Evaluate the Efficacy and Safety of BIIB074 in Neuropathic Pain From Lumbosacral Radiculopathy

CompletedNCT02935608

BiogenLumbosacral Radiculopathy

Start: 2016-10-31End: 2018-08-06Updated: 2018-08-15

Extension Study to Evaluate the Long-Term Safety, Tolerability, and Maintenance of Effect of BIIB074

TerminatedNCT02957617

BiogenNeuropathic Pain From Lumbosacral Radiculopathy

Start: 2017-02-10End: 2019-02-07Updated: 2019-02-25

Efficacy and Safety Study of BIIB074 in Participants With Small Fiber Neuropathy

TerminatedNCT03339336

BiogenDiabetes Mellitus, Small Fiber Neuropathy

Start: 2018-05-31End: 2021-04-12Updated: 2021-05-05

Phase 3

802NP301 Efficacy and Safety Study of BIIB074 in Participants With Trigeminal Neuralgia

WithdrawnNCT03070132

BiogenTrigeminal Neuralgia

Start: 2023-04-19End: 2026-08-21Updated: 2023-05-06

802NP302 Efficacy and Safety Study of BIIB074 in Participants With Trigeminal Neuralgia

WithdrawnNCT03637387

BiogenTrigeminal Neuralgia

Start: 2023-03-01End: 2026-09-29Updated: 2023-05-06

Related Papers

Efficacy and safety of vixotrigine in idiopathic or diabetes-associated painful small fibre neuropathy (CONVEY): a phase 2 placebo-controlled enriched-enrolment randomised withdrawal study.

2023-04-2718 citations

Evaluation of the Effect of Uridine Diphosphate-Glucuronosyltransferases (UGT) Inhibition by Valproic Acid on Vixotrigine Pharmacokinetics in Healthy Volunteers.

2022-08-313 citations

Design of Phase 3 Studies Evaluating Vixotrigine for Treatment of Trigeminal Neuralgia.

2020-07-0117 citations

Evaluation of the Potential Pharmacokinetic Interactions Between Vixotrigine and an Oral Contraceptive

Clinical Drug Investigation2020-06-20