BI 764198
Sponsors
Boehringer Ingelheim International GmbH, Boehringer Ingelheim International GmbH, Boehringer Ingelheim Espana S.A., Boehringer Ingelheim
Conditions
COVID-19Chronic Kidney DiseaseFocal Segmental GlomerulosclerosisFocal segmental glomerulosclerosisHealthyKidney Disease, ChronicProteinuric Kidney DiseasesProteinuric kidney diseases
Phase 1
A Study in Healthy Men Tests How Different Doses of BI 764198 Are Taken up in the Body and How Well They Are Tolerated.
CompletedNCT03854552
Start: 2019-03-15End: 2019-08-07Updated: 2026-07-06
A Study to Test How Well Healthy Men Tolerate Different Doses of BI 764198
CompletedNCT04102462
Start: 2019-10-29End: 2020-10-08Updated: 2020-11-04
A Study in People With Normal Kidney Function and People With Reduced Kidney Function to Test How BI 764198 is Processed in the Body
CompletedNCT04176536
Start: 2019-12-10End: 2020-11-17Updated: 2026-07-06
A Study in Healthy Japanese Men to Test How Well Different Doses of BI 764198 Are Tolerated
CompletedNCT04665700
Start: 2021-02-06End: 2021-10-16Updated: 2021-11-01
A Study in Healthy Men to Test How Itraconazole Influences the Amount of BI 764198 in the Blood
CompletedNCT07308652
Start: 2026-02-09End: 2026-04-10Updated: 2026-07-06
A Study in Healthy People to Test Whether BI 764198 Influences the Amount of Metformin in the Body
CompletedNCT07368569
Start: 2026-02-06End: 2026-03-17Updated: 2026-07-06
Phase 2
ACTION ON COVID-19: A Study to Test Whether BI 764198 Helps Lung Health of People Hospitalised With COVID-19
TerminatedNCT04604184
Start: 2020-11-03End: 2021-05-31Updated: 2022-04-11
A Study to Test BI 764198 in People With a Type of Kidney Disease Called Focal Segmental Glomerulosclerosis
CompletedNCT05213624
Start: 2022-05-03End: 2025-01-03Updated: 2026-01-12
A multicenter, randomized, double-blind, parallel group, placebo-controlled study to assess the efficacy, safety, tolerability, pharmacokinetics and pharmacodynamics profile of BI 764198 administered orally once daily for 12 weeks in patients with focal segmental glomerulosclerosis.
CompletedCTIS2024-511706-23-00
Start: 2022-05-31End: 2024-12-23Target: 31Updated: 2024-10-16
PODOMOUNT-Basket, a Study to Test Whether BI 764198 Helps Adults and Adolescents With Different Types of Kidney Disease
RecruitingNCT07355296
Start: 2026-03-23End: 2028-02-17Target: 132Updated: 2026-09-16
PODOMOUNT-Basket, a Phase II, multicentre, randomised, 2-arm parallel-group, double-blind, placebo-controlled basket trial to assess safety, tolerability, PK, and efficacy of BI 764198 in four proteinuric kidney diseases
Not yet recruitingCTIS2025-523425-17-00
Target: 20Updated: 2026-05-20
Phase 3
A Study to Find Out if BI 764198 Helps Adults and Adolescents With a Kidney Condition Called Focal Segmental Glomerulosclerosis (FSGS)
RecruitingNCT07220083
Start: 2026-02-16End: 2029-01-24Target: 286Updated: 2026-09-17
A multicentre, randomised, double-blind, parallel group, placebo-controlled trial to assess the effects of oral TRPC6 inhibitor BI 764198 taken over a 104 week treatment period in adult and adolescent participants with primary focal segmental glomerulosclerosis (pFSGS) or genetic FSGS related to TRPC6 gene variants
Not yet recruitingCTIS2025-522191-86-00
Target: 38Updated: 2026-03-18