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BI 456906

DRUG16 trials

Sponsors

Boehringer Ingelheim International GmbH, Boehringer Ingelheim Espana S.A., Boehringer Ingelheim RCV GmbH & Co. KG, Boehringer Ingelheim International GmbH, Boehringer Ingelheim RCV GmbH & Co. KG, Boehringer Ingelheim International GmbH, Boehringer Ingelheim RCV GmbH & Co. KG, Boehringer Ingelheim Espana S.A., Boehringer Ingelheim International GmbH, Boehringer Ingelheim

Conditions

Diabetes Mellitus, Type 2Diabetes mellitus type IIHealthyLiver DiseasesObesityOverweightRenal Impairment

Phase 1

Study to Assess Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of BI 456906 in Healthy Male Volunteers
CompletedNCT03175211
Boehringer IngelheimHealthy
Start: 2017-06-30End: 2018-02-19Updated: 2018-07-16
A Study to Test Different Doses of BI 456906 in Patients With Obesity
CompletedNCT03591718
Boehringer IngelheimObesity
Start: 2018-07-26End: 2020-04-30Updated: 2021-03-22
A Study to Test How Different Doses of BI 456906 Are Tolerated in Japanese Men With a Body Mass Index (BMI) Between 23 and 40 kg/m2
CompletedNCT04384081
Boehringer IngelheimHealthy
Start: 2020-06-01End: 2021-01-20Updated: 2021-01-26
A Study in People With Obesity to Test the Effects of BI 456906 Compared With Semaglutide on Glucagon Receptor Activity in the Liver
RecruitingNCT05202353
Boehringer IngelheimObesity
Start: 2024-10-01End: 2026-11-02Target: 30Updated: 2026-01-30
A Study to (1) Compare How BI 456906 is Taken up in the Body of Healthy People and People With Liver Problems and (2) Find Out How People With Overweight and Obesity, With and Without Liver Problems, Tolerate Different Doses of BI 456906
CompletedNCT05296733
Boehringer IngelheimHealthy, Liver Diseases, Obesity
Start: 2022-04-27End: 2023-12-29Updated: 2024-08-15
A Study in People With Overweight or Obesity to Test How Well Different Doses of BI 1820237 Are Tolerated When Given Alone or in Combination With Either Semaglutide or BI 456906
CompletedNCT05751226
Boehringer IngelheimHealthy, Obesity
Start: 2023-04-11End: 2024-08-01Updated: 2025-01-22
A Study in Women With Overweight or Obesity to Test Whether Different Doses of BI 456906 Influence the Amount of a Contraceptive in the Blood
CompletedNCT05896384
Boehringer IngelheimHealthy
Start: 2023-12-21End: 2025-03-26Updated: 2025-04-16
A Study to Test Whether Multiple Doses of BI 456906 Have an Effect on Cardiac Safety in People With Overweight or Obesity
CompletedNCT06200467
Boehringer IngelheimObesity, Overweight
Start: 2024-03-13End: 2025-10-22Updated: 2026-03-13
A Study in People With Overweight or Obesity to Test How BI 1820237, BI 456906, or a Combination of Both Affects Brain Activity
CompletedNCT06352424
Boehringer IngelheimObesity
Start: 2024-04-30End: 2025-02-24Updated: 2025-03-12
A Study to Test How BI 456906 is Taken up in the Blood of People With and Without Kidney Problems
CompletedNCT06352411
Boehringer IngelheimHealthy, Renal Impairment
Start: 2024-05-15End: 2025-09-16Updated: 2026-03-13

Phase 2

Phase 3

A Phase 3, randomised, double-blind, parallel-group, event-driven, cardiovascular safety study with BI 456906 administered subcutaneously compared with placebo in participants with overweight or obesity with established cardiovascular disease (CVD) or chronic kidney disease, and/or at least two weight-related complications or risk factors for CVD
Active, not recruitingCTIS2022-502442-27-00
Boehringer Ingelheim International GmbH, Boehringer Ingelheim Espana S.A., Boehringer Ingelheim RCV GmbH & Co. KGObesity
Start: 2024-01-08Target: 2042Updated: 2025-11-07
A Phase 3, randomised, double-blind, parallel-group, 76-week, efficacy and safety study of BI 456906 administered subcutaneously compared with placebo in participants with overweight or obesity without type 2 diabetes
Active, not recruitingCTIS2022-502529-17-00
Boehringer Ingelheim International GmbH, Boehringer Ingelheim RCV GmbH & Co. KGObesity
Start: 2024-01-18Target: 130Updated: 2025-11-13
A Phase 3, randomised, double-blind, parallel-group, 76-week, efficacy and safety study of BI 456906 administered subcutaneously compared with placebo in participants with overweight or obesity and type 2 diabetes mellitus
Active, not recruitingCTIS2022-502531-18-00
Boehringer Ingelheim International GmbH, Boehringer Ingelheim RCV GmbH & Co. KG, Boehringer Ingelheim Espana S.A.Diabetes mellitus type II, Obesity
Start: 2024-01-18Target: 248Updated: 2025-12-02
Multicentre, randomised, double-blind, placebo-controlled, 48-week, Phase III trial to evaluate the efficacy and safety of survodutide administered subcutaneously in participants with overweight or obesity and presumed or confirmed nonalcoholic steatohepatitis (NASH)
RecruitingCTIS2023-505303-23-00
Boehringer Ingelheim International GmbHObesity
Start: 2024-07-26Target: 16Updated: 2025-10-27

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