BI 409306
Sponsors
Boehringer Ingelheim
Conditions
Alzheimer DiseaseHealthyPsychotic DisordersSchizophrenia
Phase 1
Safety Tolerability and Pharmacokinetic of BI 409306
CompletedNCT01343706
Start: 2011-04-01End: 2011-08-05Updated: 2024-04-25
Assessment of Exposure of BI 409306 in Cerebrospinal Fluid (CSF) Relative to Plasma as Well as to Evaluation of the Effect of Different Doses of BI 409306 on the cGMP (Cyclic Guanosine Monophosphate) Levels in CSF in Healthy Male Volunteers
CompletedNCT01493570
Start: 2011-12-01End: 2012-02-21Updated: 2024-03-21
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Rising Doses
CompletedNCT01505894
Start: 2012-01-01End: 2012-07-01Updated: 2024-03-08
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Multiple Rising Doses of BI 409306
CompletedNCT01611311
Start: 2012-05-01End: 2012-08-01Updated: 2024-03-08
Safety and Tolerability of BI 409306 in Patients With Schizophrenia
CompletedNCT01892384
Start: 2013-06-28End: 2013-12-05Updated: 2024-04-25
Pharmacokinetics of BI 409306 After a High Fat, High Caloric Meal and After a Single Oral Dose Given at Bed Time in Healthy Volunteers
CompletedNCT02222168
Start: 2014-09-04End: 2014-10-31Updated: 2024-07-31
Drug Drug Interaction Trial With Strong CYP3A4 Inhibitor (Itraconazole) in CYP2C19 Extensive Metabolizers and Poor Metabolizers
CompletedNCT02248259
Start: 2014-10-08End: 2015-01-08Updated: 2024-04-25
BI 409306 Cardiac Safety Trial in Healthy Volunteers
CompletedNCT02438683
Start: 2015-05-04End: 2015-08-13Updated: 2024-10-26
Investigation of Pharmacokinetic Drug-drug Interaction of BI 409306 and Donepezil in Healthy Male and Female Subjects
CompletedNCT02635750
Start: 2016-01-15End: 2016-04-04Updated: 2024-08-20
Drug-drug Interaction Trial Between Rifampicin and BI 409306 in Healthy Volunteers
CompletedNCT03151499
Start: 2017-05-30End: 2017-07-11Updated: 2024-03-07
This Study Tests in Healthy Korean Women Which Effects BI 409306 and a Birth-control Pill Have on Each Other
CompletedNCT03193307
Start: 2017-06-29End: 2017-12-01Updated: 2024-03-13
This Study in Healthy Men and Women Tests How the Body Takes up BI 409306
CompletedNCT03505151
Start: 2018-04-27End: 2018-05-19Updated: 2024-08-20
This Study in Healthy Men and Women Tests Whether BI 409306 Has an Effect on the ECG (Thorough QT Study)
CompletedNCT03934203
Start: 2019-05-09End: 2019-09-06Updated: 2024-03-12
A Study in Healthy Men to Test Whether BI 409306, BI 425809 or Lamotrigine Can Reverse the Memory Problems Caused by Ketamine
CompletedNCT04602221
Start: 2020-12-01End: 2022-08-12Updated: 2024-03-12
Phase 2
Alzheimer Disease Proof of Concept Study With BI 409306 Versus Placebo
CompletedNCT02240693
Start: 2015-01-15End: 2017-10-09Updated: 2018-11-28
BI 409306 in Patients With Cognitive Impairment Due to Alzheimer's Disease.
CompletedNCT02337907
Start: 2015-01-21End: 2017-10-10Updated: 2018-11-14
This Study Tests Whether BI 409306 Prevents Patients With a Specific Type of Mental Illness (Attenuated Psychosis Syndrome) From Becoming Worse. This Study Looks at How Well Patients Tolerate the Medicine and How Effective it is Over 1 Year
TerminatedNCT03230097
Start: 2017-09-29End: 2021-04-07Updated: 2025-05-14
This Study Tests Whether BI 409306 Prevents Patients With Schizophrenia From Becoming Worse. This Study Looks at How Well Patients Tolerate BI 409306 and How Effective it is Over 6 Months
TerminatedNCT03351244
Start: 2017-12-07End: 2021-03-31Updated: 2025-05-14