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Bevacizumab-IRDye800CW

DRUG12 trials

Sponsors

University Medical Center Groningen, Technical University of Munich

Conditions

Adenomatous Polyposis ColiAge-Related Macular DegenerationBarrett EsophagusBreast CancerDysplasiaEsophageal CancerHilar CholangiocarcinomaNAMD

Phase 1

VEGF-targeted Fluorescent Tracer Imaging in Breast Cancer
CompletedNCT01508572
University Medical Center GroningenBreast Cancer
Start: 2011-10-31End: 2015-01-31Updated: 2017-10-27
Visualization of Rectal Cancer During Endoscopy, Using a Fluorescent Tracer
CompletedNCT01972373
University Medical Center GroningenRectal Cancer
Start: 2013-10-31End: 2017-01-31Updated: 2024-04-16
Molecular Fluorescence Endoscopy in Patients With Familial Adenomatous Polyposis, Using Bevacizumab-IRDye800CW
CompletedNCT02113202
University Medical Center GroningenAdenomatous Polyposis Coli
Start: 2014-03-31End: 2015-10-31Updated: 2023-10-27
VEGF-targeted Fluorescence Near-Infrared (NIR) Endoscopy in (Pre)Malignant Esophageal Lesions
CompletedNCT02129933
University Medical Center GroningenDysplasia, Esophageal Cancer
Start: 2014-04-30End: 2016-11-30Updated: 2024-04-16
Fluorescence Endoscopy of Esophageal Carcinoma
TerminatedNCT03558724
University Medical Center GroningenEsophageal Cancer
Start: 2018-10-29End: 2022-10-11Updated: 2024-04-16
Fluorescence Image Guided Surgery in Cholangiocarcinoma
NCT03620292
University Medical Center GroningenHilar Cholangiocarcinoma
Start: 2019-04-01End: 2021-12-01Target: 12Updated: 2021-04-28
FLuoresence Image Guided Surgery With A VEGF-targeted Tracer in Soft-tissue Sarcomas in Humans Approach With Bevacizumab-IRDye 800CW
CompletedNCT03913806
University Medical Center GroningenSoft Tissue Sarcoma
Start: 2018-05-01End: 2020-01-01Updated: 2020-01-28
Detection of PitNET Tissue During TSS Using Bevacizumab-800CW
CompletedNCT04212793
University Medical Center GroningenPituitary Adenoma, Pituitary Macroadenoma, Pituitary Tumor
Start: 2020-10-28End: 2022-10-24Updated: 2023-04-14
Targeted Fluorescence Imaging in AMD
CompletedNCT05262244
University Medical Center GroningenAge-Related Macular Degeneration, NAMD
Start: 2022-10-28End: 2024-03-30Updated: 2024-12-06
Thyroid Cancer and Central Lymph Node Metastases Detection Using Bevacizumab-IRDye800CW
CompletedNCT06095362
University Medical Center GroningenSurgery, Thyroid Carcinoma
Start: 2021-11-29End: 2023-10-12Updated: 2024-08-22

Phase 2

Detection of Early Esophageal Cancer by NIR-FME.
NCT03877601
University Medical Center GroningenBarrett Esophagus
Start: 2019-07-29End: 2021-10-01Target: 60Updated: 2020-11-04
Improvement of the Operative Outcome in Patients With Primary VEGF + Unifocal Breast Cancer or DCIS Through the Intraoperative Visualization of the Tumor Using Molecular Imaging and Bevacizumab-IRDye-800CW
WithdrawnNCT05359874
Technical University of MunichBreast Cancer
Start: 2021-06-30End: 2023-03-31Updated: 2022-05-04

Related Papers

Fluorescence detection of pituitary neuroendocrine tumour during endoscopic transsphenoidal surgery using bevacizumab-800CW: a non-randomised, non-blinded, single centre feasibility and dose finding trial [DEPARTURE trial].
2024-10-115 citations
Detection by fluorescence of pituitary neuroendocrine tumour (PitNET) tissue during endoscopic transsphenoidal surgery using bevacizumab-800CW (DEPARTURE trial): study protocol for a non-randomised, non-blinded, single centre, feasibility and dose-finding trial
BMJ Open2021-10-019 citations
Back-Table Fluorescence-Guided Imaging for Circumferential Resection Margin Evaluation Using Bevacizumab-800CW in Patients with Locally Advanced Rectal Cancer
Journal of Nuclear Medicine2019-10-1861 citations
Quantitative fluorescence endoscopy: an innovative endoscopy approach to evaluate neoadjuvant treatment response in locally advanced rectal cancer
Gut2019-09-1860 citations
Near-infrared fluorescence molecular endoscopy detects dysplastic oesophageal lesions using topical and systemic tracer of vascular endothelial growth factor A
Gut2017-12-15123 citations
Abstract SY36-02: Visualizing cancer: Surgical navigation using targeted fluorescent imaging agents
Cancer Research2015-08-01