BET Bromodomain Inhibitor ZEN-3694
Sponsors
Rahul Aggarwal, National Cancer Institute (NCI)
Conditions
Advanced Malignant Solid NeoplasmAdvanced NUT CarcinomaAnatomic Stage III Breast Cancer AJCC v8Anatomic Stage IV Breast Cancer AJCC v8Castration-Resistant Prostate CarcinomaLocally Advanced Pancreatic CarcinomaLocally Advanced Triple-Negative Breast CarcinomaMetastatic Breast Carcinoma
Phase 1
Testing the Combination of ZEN003694 and Nivolumab With or Without Ipilimumab in Solid Tumors
SuspendedNCT04840589
Start: 2022-02-02End: 2028-09-01Target: 66Updated: 2026-04-03
Testing the Safety and Efficacy of the Addition of a New Anti-cancer Drug, ZEN003694, to Chemotherapy Treatment (Cisplatin and Etoposide or Carboplatin and Paclitaxel) for Adult and Pediatric Patients (12-17 Years) With NUT Carcinoma
RecruitingNCT05019716
Start: 2022-07-13End: 2026-06-30Target: 36Updated: 2026-04-03
Testing A New Anti-cancer Drug Combination, Entinostat and ZEN003694, for Advanced and Refractory Solid Tumors
RecruitingNCT05053971
Start: 2022-11-16End: 2026-07-01Target: 49Updated: 2026-04-03
Testing the Combination of the Anticancer Drugs ZEN003694 and Binimetinib in Patients With Advanced/Metastatic or Unresectable Solid Tumors With RAS Alterations and Triple Negative Breast Cancer
SuspendedNCT05111561
Start: 2022-08-02End: 2027-03-14Target: 42Updated: 2026-04-03
Testing the Safety and Efficacy of the Combination of Two Anti-cancer Drugs, ZEN003694 and Abemaciclib, for Adult and Pediatric Patients (12-17 Years) With Metastatic or Unresectable NUT Carcinoma, Breast Cancer and Other Solid Tumors
RecruitingNCT05372640
Start: 2023-08-10End: 2026-06-01Target: 45Updated: 2026-04-03
Testing the Addition of Anti-Cancer Drug, ZEN003694 (ZEN-3694) and PD-1 Inhibitor (Pembrolizumab), to Standard Chemotherapy (Nab-Paclitaxel) Treatment in Patients With Advanced Triple-Negative Breast Cancer
RecruitingNCT05422794
Start: 2023-05-18End: 2027-03-31Target: 57Updated: 2026-04-03
Testing the Addition of an Anti-Cancer Drug, ZEN003694, to the Usual Chemotherapy Treatment (Capecitabine) for Metastatic or Unresectable Cancers
RecruitingNCT05803382
Start: 2023-11-08End: 2026-06-30Target: 30Updated: 2026-04-03
Testing Different Amounts of the Combination of Drugs M1774 and ZEN-3694 for the Treatment of Recurrent Ovarian and Endometrial Cancer
RecruitingNCT05950464
Start: 2023-12-18End: 2026-04-30Target: 60Updated: 2026-04-03
Testing the Addition of Anti-cancer Drug, ZEN003694, to the Usual Chemotherapy Treatment, Cetuximab Plus Encorafenib, for Colorectal Cancer
RecruitingNCT06102902
Start: 2024-06-05End: 2027-01-30Target: 30Updated: 2026-04-03
Phase 2
ZEN-3694, Enzalutamide, and Pembrolizumab for the Treatment of Metastatic Castration-Resistant Prostate Cancer
Active, not recruitingNCT04471974
Start: 2021-01-26End: 2028-05-31Updated: 2025-07-22
Testing the Combination of the Anti-cancer Drugs ZEN003694 (ZEN-3694) and Talazoparib in Patients With Advanced Solid Tumors, The ComBET Trial
RecruitingNCT05327010
Start: 2022-11-14End: 2027-12-31Target: 88Updated: 2026-04-03