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BET Bromodomain Inhibitor ZEN-3694

DRUG11 trials

Sponsors

Rahul Aggarwal, National Cancer Institute (NCI)

Conditions

Advanced Malignant Solid NeoplasmAdvanced NUT CarcinomaAnatomic Stage III Breast Cancer AJCC v8Anatomic Stage IV Breast Cancer AJCC v8Castration-Resistant Prostate CarcinomaLocally Advanced Pancreatic CarcinomaLocally Advanced Triple-Negative Breast CarcinomaMetastatic Breast Carcinoma

Phase 1

Testing the Combination of ZEN003694 and Nivolumab With or Without Ipilimumab in Solid Tumors
SuspendedNCT04840589
National Cancer Institute (NCI)Metastatic Malignant Solid Neoplasm, Recurrent Malignant Solid Neoplasm, Recurrent Platinum-Resistant Ovarian Carcinoma +1
Start: 2022-02-02End: 2028-09-01Target: 66Updated: 2026-04-03
Testing the Safety and Efficacy of the Addition of a New Anti-cancer Drug, ZEN003694, to Chemotherapy Treatment (Cisplatin and Etoposide or Carboplatin and Paclitaxel) for Adult and Pediatric Patients (12-17 Years) With NUT Carcinoma
RecruitingNCT05019716
National Cancer Institute (NCI)Advanced NUT Carcinoma, Metastatic NUT Carcinoma, Unresectable NUT Carcinoma
Start: 2022-07-13End: 2026-06-30Target: 36Updated: 2026-04-03
Testing A New Anti-cancer Drug Combination, Entinostat and ZEN003694, for Advanced and Refractory Solid Tumors
RecruitingNCT05053971
National Cancer Institute (NCI)Advanced Malignant Solid Neoplasm, Locally Advanced Pancreatic Carcinoma, Metastatic Pancreatic Carcinoma +6
Start: 2022-11-16End: 2026-07-01Target: 49Updated: 2026-04-03
Testing the Combination of the Anticancer Drugs ZEN003694 and Binimetinib in Patients With Advanced/Metastatic or Unresectable Solid Tumors With RAS Alterations and Triple Negative Breast Cancer
SuspendedNCT05111561
National Cancer Institute (NCI)Advanced Malignant Solid Neoplasm, Metastatic Malignant Solid Neoplasm, Refractory Malignant Solid Neoplasm +2
Start: 2022-08-02End: 2027-03-14Target: 42Updated: 2026-04-03
Testing the Safety and Efficacy of the Combination of Two Anti-cancer Drugs, ZEN003694 and Abemaciclib, for Adult and Pediatric Patients (12-17 Years) With Metastatic or Unresectable NUT Carcinoma, Breast Cancer and Other Solid Tumors
RecruitingNCT05372640
National Cancer Institute (NCI)Anatomic Stage III Breast Cancer AJCC v8, Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma +5
Start: 2023-08-10End: 2026-06-01Target: 45Updated: 2026-04-03
Testing the Addition of Anti-Cancer Drug, ZEN003694 (ZEN-3694) and PD-1 Inhibitor (Pembrolizumab), to Standard Chemotherapy (Nab-Paclitaxel) Treatment in Patients With Advanced Triple-Negative Breast Cancer
RecruitingNCT05422794
National Cancer Institute (NCI)Anatomic Stage III Breast Cancer AJCC v8, Anatomic Stage IV Breast Cancer AJCC v8, Locally Advanced Triple-Negative Breast Carcinoma +2
Start: 2023-05-18End: 2027-03-31Target: 57Updated: 2026-04-03
Testing the Addition of an Anti-Cancer Drug, ZEN003694, to the Usual Chemotherapy Treatment (Capecitabine) for Metastatic or Unresectable Cancers
RecruitingNCT05803382
National Cancer Institute (NCI)Metastatic Colorectal Carcinoma, Metastatic Malignant Solid Neoplasm, Stage IV Colorectal Cancer AJCC v8 +2
Start: 2023-11-08End: 2026-06-30Target: 30Updated: 2026-04-03
Testing Different Amounts of the Combination of Drugs M1774 and ZEN-3694 for the Treatment of Recurrent Ovarian and Endometrial Cancer
RecruitingNCT05950464
National Cancer Institute (NCI)Recurrent Endometrial Carcinoma, Recurrent Endometrial Clear Cell Adenocarcinoma, Recurrent Endometrial Endometrioid Adenocarcinoma +6
Start: 2023-12-18End: 2026-04-30Target: 60Updated: 2026-04-03
Testing the Addition of Anti-cancer Drug, ZEN003694, to the Usual Chemotherapy Treatment, Cetuximab Plus Encorafenib, for Colorectal Cancer
RecruitingNCT06102902
National Cancer Institute (NCI)Metastatic Colorectal Adenocarcinoma, Recurrent Colorectal Adenocarcinoma, Refractory Colorectal Adenocarcinoma +1
Start: 2024-06-05End: 2027-01-30Target: 30Updated: 2026-04-03

Phase 2

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