Best Medical Therapy

OTHER17 trials

Sponsors

University of North Carolina, Chapel Hill, US Department of Veterans Affairs, NMT Medical, Medical University of Vienna, W.L.Gore & Associates

Conditions

Aortic DiseasesCerebral InfarctionChronic Ischemic Heart DiseaseChronic Venous InsufficiencyChronic Venous ThrombosisCritical Limb IschemiaDiabetesFaecal Incontinence

Phase 1

METHOD - Bone Marrow Derived Mononuclear Cells in Chronic Ischemic Disease

TerminatedNCT01666132

Cardiocentro TicinoChronic Ischemic Heart Disease

Start: 2011-01-31End: 2015-04-30Updated: 2015-08-20

Phase 2

Evaluation of the STARFlex® Septal Closure System in Patients With a Stroke or TIA Due to the Possible Passage of a Clot of Unknown Origin Through a Patent Foramen Ovale (PFO)

NMT MedicalIschemic Attack, Transient, Patent Foramen Ovale, Stroke

Start: 2003-06-30End: 2010-04-30Target: 900Updated: 2008-12-30

Phase 3

Carotid Occlusion Surgery Study

TerminatedNCT00029146

University of North Carolina, Chapel HillCerebral Infarction, Ischemic Attack, Transient, Stroke

Start: 2002-07-31End: 2010-06-30Updated: 2012-03-27

Phase I Deep Brain Stimulation (DBS) vs. Best Medical Therapy (BMT) Trial

CompletedNCT00056563

US Department of Veterans AffairsParkinson's Disease

Start: 2002-04-30End: 2008-10-31Updated: 2014-05-09

Stage IV Surgery Versus Best Medical Therapy

TerminatedNCT01013623

Saint John's Cancer InstituteStage IV Resectable Melanoma

Start: 2009-11-30End: 2012-09-30Updated: 2012-09-26

LA-HCM Study : Rivaroxaban for Antithrombotic Prevention in Hypertrophic Cardiomyopathy Patients With Abnormal Left Atrial Strain.

RecruitingNCT07202897

Rennes University HospitalHypertrophic Cardiomyopathy (HCM)

Start: 2026-01-07End: 2033-01-07Target: 532Updated: 2026-06-12

Phase 4

Comparison of Stenting Versus Best Medical Therapy for Treatment of Ostial Renal Artery Stenosis: a Trial in Patients With Advanced Atherosclerosis

Medical University of ViennaRenal Artery Stenosis

Start: 2004-02-29Target: 120Updated: 2011-07-26

Unknown Phase

A European Study on Medical Management Versus TAG Device + Medical Management for Acute Uncomplicated Type B Dissection

CompletedNCT00742274

W.L.Gore & AssociatesAortic Diseases

Start: 2008-08-31End: 2013-10-31Updated: 2013-12-04

Electrical Stimulation in Peripheral Arterial Disease

TerminatedNCT02136537

Imperial College LondonPeripheral Arterial Disease

Start: 2014-08-31End: 2016-12-31Updated: 2019-05-09

ULCERS - Electrical Stimulation in Diabetic Foot Ulceration

CompletedNCT02211495

Imperial College LondonDiabetes

Start: 2014-07-31End: 2015-12-31Updated: 2020-11-20

Minor Stroke Therapy Evaluation

University Hospital, MontpellierStroke

Start: 2019-04-10End: 2025-10-31Target: 824Updated: 2023-08-31

Large Stroke Therapy Evaluation

TerminatedNCT03811769

University Hospital, MontpellierStroke

Start: 2019-04-07End: 2023-08-24Updated: 2025-09-29

Exercise Rehabilitation for Patients With Critical Limb Ischemia After Revascularization

University of CalgaryCritical Limb Ischemia, Peripheral Arterial Disease

Start: 2019-02-15End: 2020-07-01Target: 64Updated: 2019-05-28

Efficacy of Acupuncture as a Treatment for Faecal Incontinence

Singapore General HospitalFaecal Incontinence

Start: 2018-02-07End: 2020-11-30Target: 100Updated: 2020-03-19

Response To Medical Therapy in Inflammatory Bowel Disease Patients Carrying-out a Prescribed Exercise Programme

Royal College of Surgeons, IrelandInflammatory Bowel Diseases

Start: 2022-08-30End: 2023-05-22Target: 70Updated: 2022-11-01

Best Endovenous Treatment, Including STenting, Versus Non-endovenous Treatment in Chronic Proximal Deep Venous Disease

TerminatedNCT05622500

Imperial College LondonChronic Venous Insufficiency, Chronic Venous Thrombosis, Iliac Vein Obstruction +2

Start: 2022-09-03End: 2025-04-08Updated: 2025-06-22

DTI-guided Minimally Invasive Hematoma Evacuation for Intracerebral Hemorrhage

RecruitingNCT05891509

Zhongming QiuStroke Hemorrhagic

Start: 2023-08-03End: 2027-08-31Target: 100Updated: 2023-09-13

Related Papers

Endovascular Thrombectomy in Patients With Largest Baseline Infarcts (ASPECTS 0-2): An Ancillary Analysis of the LASTE Trial.

2026-04-14

Efficacy and safety of bridging therapy and thrombectomy alone in patients with large infarcts of unrestricted size: LASTE trial post hoc analysis.

2026-03-06

10-year clinical outcomes of subthalamic nucleus versus pallidal deep brain stimulation for Parkinson’s disease: VA/NINDS CSP #468F

Frontiers in Neurology2026-01-16

CLEAR Thrombectomy Score: An Index to Estimate the Probability of Good Functional Outcome With or Without Endovascular Treatment in the Late Window for Anterior Circulation Occlusion

Journal of the American Heart Association2024-07-0913 citations

Efficacy of Traditional Acupuncture Compared to Biofeedback Therapy in Fecal Incontinence: A Randomized Controlled Trial

Diseases of the Colon & Rectum2024-07-022 citations

Trial of Thrombectomy for Stroke with a Large Infarct of Unrestricted Size

New England Journal of Medicine2024-05-08211 citations

Evaluation of acute mechanical revascularization in large stroke (ASPECTS ⩽5) and large vessel occlusion within 7 h of last-seen-well: The LASTE multicenter, randomized, clinical trial protocol

International Journal of Stroke2023-07-1870 citations

Evaluation of acute mechanical revascularization in minor stroke (NIHSS score ⩽ 5) and large vessel occlusion: The MOSTE multicenter, randomized, clinical trial protocol.

2023-07-1612 citations

Contraintuitive fallacy in a big‐risk‐no‐gain stroke scenario? Please verify!

European Journal of Neurology2023-02-14

An Irish Multi-Centre Study of Behaviours, Attitudes and Barriers to Exercise in Inflammatory Bowel Disease, a Survey from the Patient’s Perspective

Gastrointestinal Disorders2022-12-105 citations

Impact of a physician-led exercise programme on quality of life, muscle mass and clinical response in inflammatory bowel disease patients during induction with disease-modifying therapy: a study protocol

BMJ Open Gastroenterology2022-09-01

Editors' Note: Thrombectomy vs Medical Management in Low NIHSS Acute Anterior Circulation Stroke

Neurology2021-09-13

Neuropsychological changes following deep brain stimulation surgery for Parkinson's disease: comparisons of treatment at pallidal and subthalamic targets versus best medical therapy

Journal of Neurology Neurosurgery & Psychiatry2014-09-02113 citations

Predictors of recurrent events in patients with cryptogenic stroke and patent foramen ovale within the CLOSURE I (Evaluation of the STARFlex Septal Closure System in Patients With a Stroke and/or Transient Ischemic Attack Due to Presumed Paradoxical Embolism Through a Patent Foramen Ovale) trial.

2014-08-0151 citations

Surgical results of the Carotid Occlusion Surgery Study.

2012-10-2698 citations

Closure or medical therapy for cryptogenic stroke with patent foramen ovale.

2012-03-01656 citations

Extracranial-intracranial bypass surgery for stroke prevention in hemodynamic cerebral ischemia: the Carotid Occlusion Surgery Study randomized trial.

2011-11-01518 citations

Study design of the CLOSURE I Trial: a prospective, multicenter, randomized, controlled trial to evaluate the safety and efficacy of the STARFlex septal closure system versus best medical therapy in patients with stroke or transient ischemic attack due to presumed paradoxical embolism through a patent foramen ovale.

2010-11-0443 citations

Pallidal versus subthalamic deep-brain stimulation for Parkinson's disease.

2010-06-01857 citations

Bilateral deep brain stimulation vs best medical therapy for patients with advanced Parkinson disease: a randomized controlled trial.

2009-01-011021 citations