Best medical management

DRUG14 trials

Sponsors

David Bradley MD, GI Windows, Inc., Beijing Tiantan Hospital, Fondation Ophtalmologique Adolphe de Rothschild, The First Affiliated Hospital of University of Science and Technology of China

Conditions

Acute Basilar Artery OcclusionAcute Cerebrovascular AccidentAcute IschemiaAcute Ischemic StrokeAcute Kidney InjuryAcute Mild Basilar Artery OcclusionAnterior Circulation Brain InfarctionBasilar Artery Occlusion

Phase 3

REperfusion With P2Y12 Inhibitors in Addition to mEchanical thRombectomy for perFUsion Imaging Selected Acute Stroke patiEnts

RecruitingNCT04667078

Fondation Ophtalmologique Adolphe de RothschildAcute Ischemia

Start: 2022-03-02End: 2030-09-01Target: 368Updated: 2026-03-02

Early Antiplatelet Administration After Intravenous Thrombolysis for Acute Ischemic Stroke (TREND-IVT)

RecruitingNCT06548971

Capital Medical UniversityAcute Ischemic Stroke, Cerebral Infarction

Start: 2024-11-07End: 2026-03-31Target: 1184Updated: 2025-12-19

Remote Ischemic Conditioning for Acute Ischemic Stroke Treated With Mechanical Thrombectomy（RECAST-MT）

RecruitingNCT06559241

Capital Medical UniversityAcute Ischemic Stroke, Anterior Circulation Brain Infarction

Start: 2024-09-23End: 2027-02-28Target: 2105Updated: 2025-12-10

Phase 4

Intra-arterial Recombinant Human TNK Tissue-type Plasminogen Activator (rhTNK-tPA) Thrombolysis for Acute Large Vascular Occlusion After Successful Mechanical Thrombectomy Recanalization

RecruitingNCT05624190

Beijing Tiantan HospitalIschemic Stroke, Acute

Start: 2023-02-16End: 2024-07-31Target: 256Updated: 2024-03-19

Unknown Phase

Metabolic Surgery Versus Medical Management for Resolution of Type II Diabetes

CompletedNCT01044602

David Bradley MDObesity, Type 2 Diabetes Mellitus

Start: 2010-01-31End: 2014-01-31Updated: 2015-04-21

Procedure for Duodenum to Ileal Diversion to Treat Type 2 Diabetes

Active, not recruitingNCT03130244

GI Windows, Inc.Obesity, Type 2 Diabetes

Start: 2019-09-23End: 2026-04-30Updated: 2026-04-03

Study of Endovascular Therapy in Acute Anterior Circulation Large Vessel Occlusive Patients With a Large Infarct Core

CompletedNCT04551664

Beijing Tiantan HospitalAcute Ischemic Stroke

Start: 2020-10-02End: 2023-05-30Updated: 2023-10-17

Endovascular Treatment for Acute Basilar Artery Occlusion

CompletedNCT04751708

The First Affiliated Hospital of University of Science and Technology of ChinaAcute Cerebrovascular Accident, Basilar Artery Occlusion, Stroke Due to Basilar Artery Occlusion

Start: 2021-02-21End: 2022-04-03Updated: 2022-09-15

Early RRT in AKI After Cardiac Surgery

TerminatedNCT05175053

Seoul National University HospitalAcute Kidney Injury

Start: 2021-12-24End: 2026-02-11Updated: 2026-02-12

Efficacy and Safety of Endovascular Recanalization for Acute Basilar Artery Occlusion With Extended Time Window (ANGEL-BAO)

RecruitingNCT06101667

Beijing Tiantan HospitalAcute Ischemic Stroke, Basilar Artery Occlusion

Start: 2023-10-15End: 2025-12-31Target: 224Updated: 2025-06-13

Endovascular Therapy Versus Best Medical Treatment for Acute Large Vessel Occlusion Stroke With Low NIHSS

RecruitingNCT06143488

First Affiliated Hospital of Wannan Medical CollegeAcute Ischemic Stroke, Mild Neurocognitive Disorder, Thrombectomy

Start: 2024-01-04End: 2025-09-30Target: 264Updated: 2024-01-08

Rescue Endovascular Therapy for Progressive Acute Mild Ischemic Stroke With Large Vascular Occlusion

RecruitingNCT06155032

First Affiliated Hospital of Wannan Medical CollegeCerebrovascular; Disorder, Occlusive, Stroke, Ischemic

Start: 2024-01-04End: 2026-06-30Target: 272Updated: 2025-09-12

The Efficacy and Safety of Endovascular Therapy for Acute Ischemic Stroke Due to Large Core Infarction

Not yet recruitingNCT07333950

Beijing Tiantan HospitalAcute Basilar Artery Occlusion, Endovascular Therapy, Large Core Infarction

Start: 2026-01-01End: 2028-12-31Target: 308Updated: 2026-01-12

The Efficacy and Safety of Endovascular Treatment for Acute Mild Basilar Artery Occlusion

Not yet recruitingNCT07390032

Feng GaoAcute Mild Basilar Artery Occlusion, Basilar Artery Occlusion, Endovascular Treatment

Start: 2026-03-01End: 2029-12-31Target: 230Updated: 2026-02-05

Related Papers

Effects of Computed Tomography Hyperdense Middle Cerebral Artery Sign on the Efficacy of Endovascular Therapy in Acute Ischemic Stroke With Large Infarcts: A Subgroup Analysis of the ANGEL-ASPECT Trial.

2026-03-31

Impact of enlarged perivascular spaces on endovascular therapy outcomes in patients with large ischaemic core: A post-hoc analysis of the ANGEL-ASPECT trial

Journal of Translational Internal Medicine2026-03-26

Safety and Efficacy of Early Aspirin Administration After Intravenous Thrombolysis for Acute Ischemic Stroke (TREND-IVT): Rationale and Design of a Multicenter, Randomized, Placebo-Controlled Clinical Trial.

2026-02-20

Abstract A006: The Time-Dependent Impact of Mismatch Profiles on Outcomes Following Endovascular Thrombectomy for Large Ischemic Stroke

Stroke2026-01-29

Machine learning models for predicting futile recanalisation after endovascular treatment in patients with large core infarction

Stroke and Vascular Neurology2026-01-29

Factors associated with infarct volume growth after mechanical thrombectomy in large core infarction: ANGEL-ASPECT insights.

2026-01-21

Remedial angioplasty or stenting in acute basilar artery occlusion: post hoc analysis of ATTENTION trial.

2025-12-30

Time-Dependent Impact of Mismatch Profiles on Outcomes Following Endovascular Thrombectomy for Large Ischemic Stroke.

2025-12-24

Spontaneous recanalization in acute large core ischemic stroke due to large vessel occlusion: a post-hoc analysis of the ANGEL-ASPECT trial.

2025-12-17

Significance of occlusion site on outcomes in stroke patients with large infarction undergoing endovascular therapy: A prespecified subgroup analysis of the ANGEL-ASPECT trial.

2025-11-29

Safety and Efficacy of Remote Ischaemic Conditioning for Acute Ischaemic Stroke Treated with Mechanical Thrombectomy (RECAST-MT): rationale and design.

2025-11-25

Intra-arterial tenecteplase after successful endovascular therapy (ANGEL-TNK): protocol of a multicentre, open-label, blinded end-point, prospective, randomised trial.

2025-08-2613 citations

Endovascular Therapy Versus Medical Management for Large Ischemic Infarct: 1-Year Outcomes of the ANGEL-ASPECT Trial

Stroke2025-08-251 citations

Noncontrast CT vs CT Perfusion Imaging in Patients With Basilar Artery Occlusion

Neurology2025-07-172 citations

Intra-arterial Tenecteplase for Acute Stroke After Successful Endovascular Therapy

JAMA2025-07-0522 citations

Sex-Related Differences in Endovascular Treatment Outcomes for Acute Large Infarcts: The ANGEL-ASPECT Subanalysis

Stroke2025-05-091 citations

Anaesthesia modality on endovascular therapy outcomes in patients with large infarcts: a post hoc analysis of the ANGEL-ASPECT trial.

2025-04-292 citations

Predictors of parenchymal hemorrhage after endovascular treatment in large core ischemic stroke: a post-hoc analysis of the ANGEL-ASPECT trial

Journal of NeuroInterventional Surgery2025-04-25

The Basilar Artery Collateral Simplified Score: a Novel Collateral Circulation Score Associated With Outcomes in Patients With Basilar Artery Occlusion: Results From the ATTENTION Study

Journal of the American Heart Association2025-03-13

Clinical Severity and Outcomes in Large Infarcts With Endovascular Therapy: A Post Hoc Analysis of the ANGEL-ASPECT Trial

Stroke2025-02-271 citations

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