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Balcinrenone+Dapagliflozin

DRUG2 trials

Sponsors

AstraZeneca AB

Conditions

Chronic HF and comorbid impairment of kidney function who had a recent HF event to evaluate the effect of balcinrenone/dapagliflozin versus dapagliflozin alone on HF events and cardiovascular (CV) deathChronic Kidney Disease and Albuminuria

Phase 2

A Phase IIb, Multicentre, Randomised, Double-Blind, Dose-finding Study to Evaluate the Efficacy, Safety and Tolerability of Balcinrenone in Combination with Dapagliflozin Compared with Dapagliflozin in Patients with Chronic Kidney Disease and Albuminuria
CompletedCTIS2023-509709-63-00
AstraZeneca ABChronic Kidney Disease and Albuminuria
Start: 2024-07-30End: 2025-05-09Target: 85Updated: 2025-04-23

Phase 3

A Phase III, Randomised, Double-blind Study to Evaluate the Effect of Balcinrenone/Dapagliflozin, Compared with Dapagliflozin, on the Risk of Heart Failure Events and Cardiovascular Death in Patients with Heart Failure and Impaired Kidney Function
RecruitingCTIS2023-508162-15-00
AstraZeneca ABChronic HF and comorbid impairment of kidney function who had a recent HF event to evaluate the effect of balcinrenone/dapagliflozin versus dapagliflozin alone on HF events and cardiovascular (CV) death
Start: 2024-07-12Target: 1194Updated: 2026-01-20