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Bacteriophage

DRUG7 trials

Sponsors

National Institute of Allergy and Infectious Diseases (NIAID), Southwest Regional Wound Care Center, Northern State Medical University, Intralytix, Inc., Adaptive Phage Therapeutics, Inc.

Conditions

Abdominal SepsisAcute Respiratory Distress SyndromeBrain InjuriesEncephalitisEndocarditis, BacterialImmunoproliferative DisorderMeningitisPancreatitis

Early Phase 1

A Randomized Controlled Trial (RCT) of Yiqi Huoxue Jiedu Formula Combined With Bacteriophages in the Treatment of Severe Pneumonia Caused by Drug-resistant Gram-negative Bacilli
Not yet recruitingNCT07338123
Chinese PLA General HospitalPneumonia
Start: 2026-02-01End: 2029-08-31Target: 240Updated: 2026-01-13

Phase 1

A Prospective, Randomized, Double-Blind Controlled Study of WPP-201 for the Safety and Efficacy of Treatment of Venous Leg Ulcers
CompletedNCT00663091
Southwest Regional Wound Care CenterVenous Leg Ulcers
Start: 2006-09-30End: 2008-05-31Updated: 2011-09-07
Safety and Efficacy of the Bacteriophage Preparation, ShigActive™, in a Human Experimental Model of Shigellosis
Active, not recruitingNCT05182749
Intralytix, Inc.Shigellosis
Start: 2023-02-23End: 2025-09-30Target: 52Updated: 2025-06-15

Phase 2

Study of Immune Responses and Safety of Recombinant Human CD40 Ligand in Patients With X-Linked Hyper-IgM Syndrome
CompletedNCT00001145
National Institute of Allergy and Infectious Diseases (NIAID)Immunoproliferative Disorder
Start: 1999-10-31End: 2003-10-31Target: 5Updated: 2008-03-04
Bacteriophage Therapy in Patients With Prosthetic Joint Infections (PJI)
WithdrawnNCT05269134
Adaptive Phage Therapeutics, Inc.Prosthetic Joint Infection
Start: 2023-03-27End: 2027-07-31Updated: 2023-11-30

Phase 3

Bacteriophages in Addition to Antibiotics for the Treatment of Patients With Infective Endocarditis
RecruitingNCT06870409
University Clinical Hospital na V.V.Vinogradov (branch of RUDN university na Patrice Lumumba)Endocarditis, Bacterial
Start: 2025-02-05End: 2029-02-05Target: 30Updated: 2026-03-19

Unknown Phase

The Effect of Supraglottic and Oropharyngeal Decontamination on the Incidence of Ventilator-associated Pneumonia
CompletedNCT04325685
Northern State Medical UniversityAbdominal Sepsis, Acute Respiratory Distress Syndrome, Brain Injuries +5
Start: 2020-01-01End: 2023-11-07Updated: 2023-11-08