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Bacillus Calmette-Guérin

BIOLOGICAL6 trials

Sponsors

Medical Enterprises Europe B.V., Massachusetts General Hospital, Aeras

Conditions

Autoimmune DiabetesCovid19Diabetes MellitusDiabetes Mellitus, Type 1Diabetes Mellitus, Type IDiabetes Mellitus, Type OneDiabetes type1Malignant Tumor of Urinary Bladder

Early Phase 1

Biological Samples Obtained by Leukapheresis Induced by Two BCG Vaccinations in BCG-naïve Healthy Adults in the US
CompletedNCT03175380
AerasTuberculosis
Start: 2017-08-08End: 2019-01-10Updated: 2019-09-04

Phase 2

Repeat BCG Vaccinations for the Treatment of Established Type 1 Diabetes
Active, not recruitingNCT02081326
Massachusetts General HospitalAutoimmune Diabetes, Covid19, Diabetes Mellitus, Type I +1
Start: 2015-06-01End: 2031-07-01Target: 150Updated: 2026-04-13
Repeat BCG Vaccinations For The Treatment Of Pediatric Type 1 Diabetes
Active, not recruitingNCT05180591
Massachusetts General HospitalAutoimmune Diabetes, Diabetes Mellitus, Type 1, Diabetes type1
Start: 2022-03-22End: 2031-03-01Target: 150Updated: 2026-06-26
Repeat BCG Vaccinations for the Treatment of New Onset Type 1 Diabetes in Children Age 8-<18 Years
Active, not recruitingNCT05866536
Massachusetts General HospitalAutoimmune Diabetes, Diabetes Mellitus, Diabetes type1 +1
Start: 2023-05-04End: 2031-05-01Target: 100Updated: 2026-06-26

Phase 3

Hyperthermia Treatment in Conjunction With Mitomycin C Versus Bacillus Calmette-Guérin Immunotherapy (BCG) for Superficial Bladder Cancer
TerminatedNCT00384891
Medical Enterprises Europe B.V.Malignant Tumor of Urinary Bladder, Neoplasms, Neoplasms by Site +5
Start: 2002-02-28End: 2013-12-31Updated: 2014-10-07
SHTC - EUROPE-1 Synergo Hyperthermia-Chemotherapy by European Urologists' Research Operation Preserving Evolution Study I
WithdrawnNCT02254915
Medical Enterprises Europe B.V.Neoplasms, Neoplasms by Site, Urinary Bladder Diseases +4
Updated: 2015-04-01

Related Papers

2862-LB: Phase II Clinical Trial of BCG Immunotherapy for Type 1 Diabetes with Juvenile Onset: Five-Year Analysis of Safety, HbA1c, Time in Range, and Insulin Use
Diabetes2026-06-05
2861-LB: Phase II Clinical Trial of BCG Immunotherapy for Latent Autoimmune Diabetes in Adults (LADA): Five-Year Analysis of HbA1c, Insulin Use, and Pancreatic C-Peptide Outcomes
Diabetes2026-06-05
Results of a Randomised Controlled Trial Comparing Intravesical Chemohyperthermia with Mitomycin C Versus Bacillus Calmette-Guérin for Adjuvant Treatment of Patients with Intermediate- and High-risk Non-Muscle-invasive Bladder Cancer.
2016-01-20159 citations