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B7-H3-CAR T cells

DRUG2 trials

Sponsors

St. Jude Children's Research Hospital

Conditions

Atypical Teratoid/Rhabdoid TumorCentral Nervous System NeoplasmsChildhood OsteosarcomaChildhood RhabdomyosarcomaChildhood Soft Tissue SarcomaDiffuse Midline Glioma, H3 K27M-MutantEpendymomaEwing Sarcoma

Phase 1

Loc3CAR: Locoregional Delivery of B7-H3-CAR T Cells for Pediatric Patients With Primary CNS Tumors
Active, not recruitingNCT05835687
St. Jude Children's Research HospitalAtypical Teratoid/Rhabdoid Tumor, Central Nervous System Neoplasms, Diffuse Midline Glioma, H3 K27M-Mutant +4
Start: 2023-04-27End: 2028-03-01Updated: 2026-07-06
Hypofractionated Radiation in Combination With B7-H3-CAR T Cells for Pediatric Patients With Relapsed/Refractory Sarcomas
RecruitingNCT07222735
St. Jude Children's Research HospitalChildhood Osteosarcoma, Childhood Rhabdomyosarcoma, Childhood Soft Tissue Sarcoma +2
Start: 2026-01-21End: 2031-11-05Target: 42Updated: 2026-02-09

Related Papers

TIRTL-sequencing to interrogate the clonal repertoire of CARpos and CARneg TILs post CAR T-cell therapy for pediatric solid tumors 2259261
The Journal of Immunology2026-07-28
BIOM-41. CELL-FREE DNA ANALYSIS OF CSF SAMPLES ENABLES ASSESSMENT OF TREATMENT RESPONSE AND TRACKING OF CAR T-CELLS POST-LOCOREGIONAL DELIVERY IN PEDIATRIC BRAIN TUMOR PATIENTS
Neuro-Oncology2025-11-01
EXTH-34. Increased capacity for expansion, not persistence, improves preclinical B7-H3 targeted CAR T cell therapy against aggressive Group 3 medulloblastomas
Neuro-Oncology2025-11-01
NCMP-26. Tumor inflammation-associated neurotoxicities for patients treated with intracranial B7-H3-CAR T cells on a phase I clinical trial
Neuro-Oncology2025-11-01
CTP-13. Locoregional B7-H3 CAR-T cells for relapsed/refractory CNS tumors: preliminary clinical experience of the Loc3CAR trial
Neuro-Oncology2025-11-01
Abstract PR014: Robust disease monitoring using CSF liquid biopsies collected from children undergoing cellular therapy for malignant central nervous system tumors
Clinical Cancer Research2024-11-131 citations
CTIM-15. LOCOREGIONAL ADMINISTRATION OF B7-H3-CAR T CELLS EXPRESSING 41BB LIGAND FOR PEDIATRIC PATIENTS WITH PRIMARY CNS TUMORS: PRELIMINARY RESULTS FROM A PHASE I STUDY
Neuro-Oncology2024-11-013 citations