AZD7789
Sponsors
AstraZeneca AB, AstraZeneca AB, AstraZeneca AB, Astrazeneca AB, AstraZeneca
Conditions
Advanced or Metastatic NSCLCAdvanced or Metastatic Non-small Cell Lung Cancer (NSCLC)Advanced or Metastatic Non-small Cell Lung CarcinomaAdvanced or Metastatic Solid TumorsAdvanced or metastatic gastric and gastro-esophageal junction (GEJ) adenocarcinomaCarcinoma, Non-Small-Cell LungGastric CancerGastroesophageal Junction Cancer
Phase 1
Phase 1b Study of Dato-DXd in Combination With Immunotherapy With or Without Carboplatin in Advanced or Metastatic Non-Small Cell Lung Cancer
Active, not recruitingNCT04612751
Start: 2021-02-02End: 2026-04-30Updated: 2025-12-18
A Study to Assess the Safety and Efficacy of AZD7789 in Participants With Advanced or Metastatic Solid Cancer
Active, not recruitingNCT04931654
Start: 2021-09-28End: 2026-08-12Updated: 2025-10-09
A Phase I/II Open-label, Multi-center Study to Assess Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of AZD7789, an anti-PD-1 and anti-TIM-3 Bispecific Antibody, in Patients with Relapsed or Refractory Classical Hodgkin Lymphoma
CompletedCTIS2022-502773-41-00
Start: 2022-06-16End: 2025-09-04Target: 78Updated: 2024-09-20
A Phase I/IIa Open-label Dose Escalation and Expansion Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Efficacy of AZD7789, an anti-PD-1 and anti-TIM-3 Bispecific Antibody, in Participants with Advanced or Metastatic Solid Tumors
CompletedCTIS2022-502774-17-00
Start: 2021-10-04End: 2025-02-27Target: 95Updated: 2025-02-17
A Phase 1b, Multicenter, 2-Part, Open-Label Study of Datopotamab Deruxtecan (Dato-DXd) in Combination with Immunotherapy with or without Carboplatin in Participants with Advanced or Metastatic Non‑Small Cell Lung Cancer (Tropion-Lung04)
Active, not recruitingCTIS2023-505992-54-00
Start: 2022-10-21Target: 75Updated: 2025-10-15