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AZD6738

DRUG19 trials

Sponsors

AstraZeneca AB, Centre Hospitalier Regional De Marseille, Royal Marsden NHS Foundation Trust, Joseph Paul Eder, Samsung Medical Center

Conditions

AdenocarcinomaAdvanced Breast CancerAdvanced Cancer Whose Tumours Contain Molecular AlterationsBile Duct CancerBreast NeoplasmCancerCarcinoma, Squamous CellChemotherapy Effect

Phase 1

Phase 2

OLAParib COmbinations
TerminatedNCT02576444
Joseph Paul EderCancer
Start: 2015-11-30End: 2019-11-18Updated: 2022-12-28
National Lung Matrix Trial: Multi-drug Phase II Trial in Non-Small Cell Lung Cancer
Active, not recruitingNCT02664935
University of BirminghamAdenocarcinoma, Carcinoma, Squamous Cell, Non-Small Cell Lung Cancer
Start: 2015-05-31End: 2025-09-30Updated: 2025-05-21
The UK Plasma Based Molecular Profiling of Advanced Breast Cancer to Inform Therapeutic CHoices (plasmaMATCH) Trial
NCT03182634
Institute of Cancer Research, United KingdomAdvanced Breast Cancer
Start: 2016-12-15End: 2023-11-30Target: 1150Updated: 2019-01-22
Study of AZD6738 and Olaparib Combination Therapy in Relapsed Small Cell Lung Cancer Patients [SUKSES-N2]
CompletedNCT03428607
Samsung Medical CenterSCLC
Start: 2018-10-17End: 2021-01-15Updated: 2021-02-18
Combination ATR and PARP Inhibitor (CAPRI) Trial With AZD6738 and Olaparib in Recurrent Ovarian Cancer
CompletedNCT03462342
University of PennsylvaniaHigh Grade Serous Carcinoma
Start: 2018-03-09End: 2025-07-21Updated: 2026-03-17
PHOENIX DDR/Anti-PD-L1 Trial: A Pre-surgical Window of Opportunity and Post-surgical Adjuvant Biomarker Study of DNA Damage Response Inhibition With or Without Anti-PD-L1 Immunotherapy in Patients With Neoadjuvant Treatment Resistant Residual Triple Negative Breast Cancer
RecruitingNCT03740893
Institute of Cancer Research, United KingdomBreast Neoplasm, HRD, Triple Negative Breast Cancer (TNBC)
Start: 2019-10-15End: 2029-06-30Target: 119Updated: 2025-08-11
This Study is a Phase II Study of AZD6738 in Combination With Durvalumab in Patients With Solid Tumor (Cohort A (N=30): GC Who Have Failed Secondary Chemotherapy Treatments Regimen; Cohort B (B=30): Melanoma Patients Who Have Failed to IO)
NCT03780608
Samsung Medical CenterGastric Adenocarcinoma, Malignant Melanoma
Start: 2019-07-30End: 2023-12-01Updated: 2022-06-15
Targeting Resistant Prostate Cancer With ATR and PARP Inhibition (TRAP Trial)
Active, not recruitingNCT03787680
University of Michigan Rogel Cancer CenterProstate Cancer
Start: 2019-10-31End: 2028-08-01Updated: 2026-03-23
DDR-Umbrella Study of DDR Targeting Agents in Advanced Biliary Tract Cancer
Active, not recruitingNCT04298021
Seoul National University HospitalBile Duct Cancer, Chemotherapy Effect
Start: 2020-06-25End: 2024-12-31Target: 74Updated: 2024-04-19
AZD6738 Plus Durvalumab in Biliary Tract Cancer
RecruitingNCT04298008
Seoul National University HospitalBile Duct Cancer, Chemotherapy Effect
Start: 2020-06-25End: 2025-12-31Target: 26Updated: 2024-04-19
An Open-Label, Multi-Drug, Biomarker-Directed, Multi-Centre Phase II Umbrella Study in Patients with Non-Small Cell Lung Cancer, who Progressed on an anti-PD-1/PD-L1 Containing Therapy (HUDSON).
Active, not recruitingCTIS2023-509004-15-00
AstraZeneca ABPatients with non-small cell lung cancer (NSCLC).
Start: 2018-02-20Target: 172Updated: 2025-06-05
A Modular Phase 2a Multicentre Open-Label Study to Investigate DNA-damage Response Agents (or Combinations) in Patients With Advanced Cancer Whose Tumours Contain Molecular Alterations (PLANETTE)
CompletedCTIS2024-515102-12-00
AstraZeneca ABAdvanced Cancer Whose Tumours Contain Molecular Alterations
Start: 2021-11-02End: 2024-10-15Target: 1Updated: 2024-08-12
A Phase II, Open Label, Randomised, Multi-centre Study to Assess the Safety and Efficacy of Agents Targeting DNA Damage Repair in Combination with Olaparib versus Olaparib Monotherapy in the Treatment of Metastatic Triple Negative Breast Cancer Patients Stratified by Alterations in Homologous Recombinant Repair (HRR)-related Genes (including BRCA1/2) (VIOLETTE)
Active, not recruitingCTIS2024-514205-60-00
AstraZeneca ABTriple Negative Breast Cancer
Start: 2018-02-15Target: 3Updated: 2025-09-24
Precision Immuno-Oncology for advanced Non-small cell lung cancer patients with PD-1 ICI Resistance (PIONeeR clinical study)
CompletedCTIS2024-515532-72-00
Centre Hospitalier Regional De Marseillenon small cell lung cancer
Start: 2019-10-08End: 2025-08-11Target: 130Updated: 2025-08-19

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