AZD6738
Sponsors
AstraZeneca AB, Centre Hospitalier Regional De Marseille, Royal Marsden NHS Foundation Trust, Joseph Paul Eder, Samsung Medical Center
Conditions
AdenocarcinomaAdvanced Breast CancerAdvanced Cancer Whose Tumours Contain Molecular AlterationsBile Duct CancerBreast NeoplasmCancerCarcinoma, Squamous CellChemotherapy Effect
Phase 1
Phase I Study to Assess Safety of AZD6738 Alone and in Combination With Radiotherapy in Patients With Solid Tumours
NCT02223923
Start: 2014-07-31End: 2025-12-30Target: 87Updated: 2025-08-01
Study of AZD6738, DNA Damage Repair/Novel Anti-cancer Agent, in Combination With Paclitaxel, in Refractory Cancer
CompletedNCT02630199
Start: 2015-12-31End: 2021-04-19Updated: 2022-06-15
Platform Study for the Treatment of Relapsed or Refractory Aggressive Non-Hodgkin's Lymphoma (PRISM Study)
CompletedNCT03527147
Start: 2018-06-19End: 2021-03-31Updated: 2022-08-15
AZD6738 & Gemcitabine as Combination Therapy
NCT03669601
Start: 2019-10-15End: 2024-09-30Target: 55Updated: 2021-06-04
AZD6738 for Patients With Progressive MDS or CMML
Active, not recruitingNCT03770429
Start: 2019-08-05End: 2026-05-31Target: 52Updated: 2025-09-29
Phase 2
OLAParib COmbinations
TerminatedNCT02576444
Start: 2015-11-30End: 2019-11-18Updated: 2022-12-28
National Lung Matrix Trial: Multi-drug Phase II Trial in Non-Small Cell Lung Cancer
Active, not recruitingNCT02664935
Start: 2015-05-31End: 2025-09-30Updated: 2025-05-21
The UK Plasma Based Molecular Profiling of Advanced Breast Cancer to Inform Therapeutic CHoices (plasmaMATCH) Trial
NCT03182634
Start: 2016-12-15End: 2023-11-30Target: 1150Updated: 2019-01-22
Study of AZD6738 and Olaparib Combination Therapy in Relapsed Small Cell Lung Cancer Patients [SUKSES-N2]
CompletedNCT03428607
Start: 2018-10-17End: 2021-01-15Updated: 2021-02-18
Combination ATR and PARP Inhibitor (CAPRI) Trial With AZD6738 and Olaparib in Recurrent Ovarian Cancer
CompletedNCT03462342
Start: 2018-03-09End: 2025-07-21Updated: 2026-03-17
PHOENIX DDR/Anti-PD-L1 Trial: A Pre-surgical Window of Opportunity and Post-surgical Adjuvant Biomarker Study of DNA Damage Response Inhibition With or Without Anti-PD-L1 Immunotherapy in Patients With Neoadjuvant Treatment Resistant Residual Triple Negative Breast Cancer
RecruitingNCT03740893
Start: 2019-10-15End: 2029-06-30Target: 119Updated: 2025-08-11
This Study is a Phase II Study of AZD6738 in Combination With Durvalumab in Patients With Solid Tumor (Cohort A (N=30): GC Who Have Failed Secondary Chemotherapy Treatments Regimen; Cohort B (B=30): Melanoma Patients Who Have Failed to IO)
NCT03780608
Start: 2019-07-30End: 2023-12-01Updated: 2022-06-15
Targeting Resistant Prostate Cancer With ATR and PARP Inhibition (TRAP Trial)
Active, not recruitingNCT03787680
Start: 2019-10-31End: 2028-08-01Updated: 2026-03-23
DDR-Umbrella Study of DDR Targeting Agents in Advanced Biliary Tract Cancer
Active, not recruitingNCT04298021
Start: 2020-06-25End: 2024-12-31Target: 74Updated: 2024-04-19
AZD6738 Plus Durvalumab in Biliary Tract Cancer
RecruitingNCT04298008
Start: 2020-06-25End: 2025-12-31Target: 26Updated: 2024-04-19
An Open-Label, Multi-Drug, Biomarker-Directed, Multi-Centre Phase II Umbrella Study in Patients with Non-Small Cell Lung Cancer, who Progressed on an anti-PD-1/PD-L1 Containing Therapy (HUDSON).
Active, not recruitingCTIS2023-509004-15-00
Start: 2018-02-20Target: 172Updated: 2025-06-05
A Modular Phase 2a Multicentre Open-Label Study to Investigate DNA-damage Response Agents (or Combinations) in Patients With Advanced Cancer Whose Tumours Contain Molecular Alterations (PLANETTE)
CompletedCTIS2024-515102-12-00
Start: 2021-11-02End: 2024-10-15Target: 1Updated: 2024-08-12
A Phase II, Open Label, Randomised, Multi-centre Study to Assess the Safety and Efficacy of Agents Targeting DNA Damage Repair in Combination with Olaparib versus Olaparib Monotherapy in the Treatment of Metastatic Triple Negative Breast Cancer Patients Stratified by Alterations in Homologous Recombinant Repair (HRR)-related Genes (including BRCA1/2) (VIOLETTE)
Active, not recruitingCTIS2024-514205-60-00
Start: 2018-02-15Target: 3Updated: 2025-09-24
Precision Immuno-Oncology for advanced Non-small cell lung cancer patients with PD-1 ICI Resistance (PIONeeR clinical study)
CompletedCTIS2024-515532-72-00
Start: 2019-10-08End: 2025-08-11Target: 130Updated: 2025-08-19
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