AZD5004
Sponsors
AstraZeneca AB, AstraZeneca, Eccogene
Conditions
Diabetes Mellitus, Type 2Healthy ParticipantsHepatic ImpairmentObesity or OverweightParticipants living with Obesity or Overweight with at least 1 comorbidityRenal ImpairmentType 2 DiabetesType 2 Diabetes Mellitus
Phase 1
A Study to Investigate Multiple Ascending Doses and Relative Bioavailability of AZD5004 in Healthy Participants
CompletedNCT06555822
Start: 2024-08-15End: 2025-03-06Updated: 2025-03-17
A Phase I Study to Investigate the Effect of Renal Impairment on the Pharmacokinetics, Safety, and Tolerability of AZD5004
CompletedNCT06742762
Start: 2024-12-17End: 2025-04-20Updated: 2025-06-08
Study to Investigate the Effect of Hepatic Impairment on the Pharmacokinetics, Safety, and Tolerability of AZD5004
CompletedNCT06813781
Start: 2024-12-19End: 2025-10-02Updated: 2025-10-15
A Study to Investigate the Impact of Multiple Doses of Itraconazole on AZD5004 in Healthy Participants and Multiple Doses of AZD5004 on Combined Oral Ethinyl Oestradiol and Levonorgestrel in Healthy Female Participants
CompletedNCT06942936
Start: 2025-05-28End: 2026-01-28Updated: 2026-02-03
A Study to Investigate the Effect of AZD5004 on Rosuvastatin, Atorvastatin, Simvastatin, Repaglinide and the Effect of Erythromycin on AZD5004 in Healthy Participants
CompletedNCT06948747
Start: 2025-05-06End: 2025-10-03Updated: 2025-10-10
A Phase Ib Study of AZD5004 in Chinese Participants With Overweight/Obesity With or Without Type 2 Diabetes Mellitus
CompletedNCT06988553
Start: 2025-06-17End: 2025-11-28Updated: 2025-12-23
A Study in Healthy Participants to Investigate Relative Bioavailability of AZD5004 in Three Solid Oral Formulations
CompletedNCT06996886
Start: 2025-05-22End: 2025-07-25Updated: 2025-07-31
A Study to Investigate the Effect of AZD5004 on Mitiglinide and Pioglitazone in Healthy Participants
RecruitingNCT07444424
Start: 2026-03-13End: 2026-07-02Target: 32Updated: 2026-03-30
A Study to Investigate the Pharmacokinetics of Different Formulations and Safety of AZD5004 in Healthy Participants Aged 18 to 55 Years
RecruitingNCT07455825
Start: 2026-03-05End: 2026-06-01Target: 64Updated: 2026-03-12
Phase 2
Efficacy, Safety, and Tolerability of Once Daily Oral Administration of AZD5004 Versus Placebo for 26 Weeks in Adults With Type 2 Diabetes Mellitus.
CompletedNCT06579105
Start: 2024-10-08End: 2025-12-19Updated: 2026-01-13
Effects of AZD5004 in Adults Who Are Living With Obesity or Overweight With at Least 1 Weight-related Comorbidity
CompletedNCT06579092
Start: 2024-10-08End: 2025-11-21Updated: 2025-12-18
A Phase IIb Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy, Safety and Tolerability of AZD5004 in Participants Living with Obesity or Overweight with Comorbidity
CompletedCTIS2024-513691-18-00
Start: 2024-12-11End: 2025-11-20Target: 30Updated: 2025-11-24
A Phase Ilb, Randomized, Double-blind, Placebo controlled and Open-label Active Comparator Study to Evaluate the Efficacy, Safety, and Tolerability of AZD5004 in Adults with Type 2 Diabetes Mellitus
CompletedCTIS2024-512562-34-00
Start: 2025-02-24End: 2025-12-17Target: 118Updated: 2025-11-19