AZD0901
Sponsors
AstraZeneca AB, AstraZeneca
Conditions
Advanced/Metastatic Gastric cancerBiliary Tract CancerGastric CancerGastric cancerGastroesophageal AdenocarcinomaGastroesophageal Junction Adenocarcinoma Expressing Claudin18.2Gastroesophageal Junction CancerLocally Advanced Resectable Gastroesophageal Adenocarcinoma
Phase 1
Phase 2
Novel Combinations in Participants With Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma
RecruitingNCT05702229
Start: 2023-01-16End: 2029-05-31Target: 163Updated: 2026-03-18
AZD0901 in Participants With Advanced Solid Tumours Expressing Claudin18.2
RecruitingNCT06219941
Start: 2023-12-13End: 2027-09-30Target: 224Updated: 2026-02-12
A Master Protocol of an Open-Label, Multi-Drug, Multi-Centre, Phase II Study to Evaluate the Efficacy, Safety, Tolerability, Pharmacokinetics, and Immunogenicity of Novel Combinations in Participants with Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma.
RecruitingCTIS2024-510977-27-00
Start: 2023-04-14Target: 8Updated: 2025-10-23
A Study of Novel Agents or Combinations as Perioperative Treatment in Participants With Locally Advanced Resectable Gastroesophageal Adenocarcinoma
RecruitingNCT07069712
Start: 2025-07-17End: 2028-09-06Target: 100Updated: 2026-03-10
A Study to Investigate the Effects of AZD0901 Monotherapy in Adult Participants With 2L+ Advanced or Metastatic Gastric or GEJ Adenocarcinoma Expressing CLDN18.2
Active, not recruitingNCT07143604
Start: 2025-08-29End: 2027-09-28Updated: 2026-03-17
A Master Protocol for an Open-Label, Multi-Drug, Multi-Center, Phase II Platform Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Anti-Tumor Activity of Novel Agents or Combinations as Perioperative Treatment in Participants with Locally Advanced Resectable Gastroesophageal Adenocarcinoma (GEMINI-PeriOp GC)
RecruitingCTIS2024-516909-23-00
Start: 2025-10-28Target: 17Updated: 2025-12-19
Phase 3
AZD0901 Compared With Investigator's Choice of Therapy in Participants With Second- or Later-line Advanced or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma Expressing Claudin18.2
RecruitingNCT06346392
Start: 2024-03-04End: 2026-09-14Target: 572Updated: 2026-03-09
A Phase III Multi-center, Open-label, Sponsor-blinded, Randomized Study of AZD0901 Monotherapy Compared With Investigator’s Choice of Therapy in Second- or Later-Line Adult Participants with Advanced/Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma Expressing Claudin 18.2 (CLARITY-Gastric 01)
RecruitingCTIS2023-508276-11-00
Start: 2025-01-17Target: 91Updated: 2025-09-15