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AZD0120

BIOLOGICAL12 trials

Sponsors

AstraZeneca AB, AstraZeneca, Alexion Pharmaceuticals, Inc., Tongji Hospital, Saurabh Dahiya

Conditions

AmyloidosisCytopeniaHighly Sensitized Patients Awaiting Kidney TransplantIdiopathic Inflammatory MyopathiesLight Chain AmyloidosisLupus Erythematosus, SystemicMultiple MyelomaNewly Diagnosed Multiple Myeloma

Early Phase 1

Phase 1

Phase 3

A Study Comparing AZD0120, a Dual-targeted CAR-T Against B-cell Maturation Antigen (BCMA) and CD19, Versus Standard Regimens in Participants With Relapsed Refractory Multiple Myeloma (DURGA-4)
RecruitingNCT07391657
AstraZenecaRelapsed Refractory Multiple Myeloma
Start: 2026-02-23End: 2030-07-29Target: 508Updated: 2026-09-01
A Phase III Open-label, Randomised, Multicentre Study Comparing AZD0120, a Dual-Targeting Autologous Chimeric Antigen Receptor T-cell (CAR-T) Therapy Directed Against BCMA and CD19, versus Standard Regimens in Participants with Relapsed Refractory Multiple Myeloma (DURGA-4)
Not yet recruitingCTIS2025-523285-25-00
AstraZeneca ABRelapsed or Refractory Multiple Myeloma
Target: 38Updated: 2026-04-30
A Phase III, Multicentre Study to Evaluate Consolidation Treatment With AZD0120 Compared With ASCT, in Participants With Newly Diagnosed Multiple Myeloma Who Are Transplant Eligible (DURGA-6).
Not yet recruitingNCT07735637
AstraZenecaNewly Diagnosed Multiple Myeloma (NDMM)
Start: 2026-08-25End: 2039-11-09Target: 750Updated: 2026-07-30
Study of AZD0120 in Newly Diagnosed Multiple Myeloma Ineligible for ASCT
RecruitingNCT07764978
AstraZenecaNewly Diagnosed Multiple Myeloma
Start: 2026-06-26End: 2034-05-12Target: 750Updated: 2026-08-14
A Phase III Open-Label, Randomised, Multicentre Study of Consolidation with a Single Administration of AZD0120, a Dual-Targeting Autologous Chimeric Antigen Receptor T-cell (CAR T) Therapy Directed Against BCMA and CD19, Compared with Continuous Standard Therapy in Participants with NDMM Who Are Ineligible to Receive ASCT as Initial Therapy (DURGA-5).
Not yet recruitingCTIS2025-524014-29-00
AstraZeneca ABNewly Diagnosed Multiple Myeloma
Target: 234Updated: 2026-09-04

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