AZD0120
Sponsors
AstraZeneca AB, AstraZeneca, Alexion Pharmaceuticals, Inc., Tongji Hospital, Saurabh Dahiya
Conditions
AmyloidosisCytopeniaHighly Sensitized Patients Awaiting Kidney TransplantIdiopathic Inflammatory MyopathiesLight Chain AmyloidosisLupus Erythematosus, SystemicMultiple MyelomaNewly Diagnosed Multiple Myeloma
Early Phase 1
Phase 1
AZD0120 in Relapsed/Refractory Multiple Myeloma (DURGA-1)
RecruitingNCT05850234
Start: 2023-07-20End: 2029-01-25Target: 232Updated: 2026-08-17
A Study to Investigate the Safety, Tolerability, and Efficacy of AZD0120 in Adults With Refractory SLE
RecruitingNCT06897930
Start: 2025-04-21End: 2029-05-01Target: 150Updated: 2026-09-10
A Phase I, Open-label, Multicenter Study to Evaluate the Safety, Tolerability, Cellular Kinetics, Immunogenicity, Pharmacodynamics, and Preliminary Efficacy of AZD0120 in Participants With Multiple Myeloma (DURGA-2)
RecruitingNCT07073547
Start: 2025-07-31End: 2028-05-26Target: 40Updated: 2026-07-13
A Phase 1b/2 Study of CAR T Cell Therapy Targeting CD19 and BCMA in Participants With Relapsed or Refractory AL Amyloidosis.
RecruitingNCT07081646
Start: 2025-08-18End: 2031-02-14Target: 91Updated: 2026-07-02
A Study of AZD0120 in Autoimmune Diseases
RecruitingNCT07295847
Start: 2026-01-09End: 2028-02-22Target: 27Updated: 2026-07-28
Autoimmune Cytopenia Elimination by Chimeric Antigen Receptor T-cell Therapy
Not yet recruitingNCT07790575
Start: 2026-09-01End: 2041-07-01Target: 16Updated: 2026-08-27
Phase 3
A Study Comparing AZD0120, a Dual-targeted CAR-T Against B-cell Maturation Antigen (BCMA) and CD19, Versus Standard Regimens in Participants With Relapsed Refractory Multiple Myeloma (DURGA-4)
RecruitingNCT07391657
Start: 2026-02-23End: 2030-07-29Target: 508Updated: 2026-09-01
A Phase III Open-label, Randomised, Multicentre Study Comparing AZD0120, a Dual-Targeting Autologous Chimeric Antigen Receptor T-cell (CAR-T) Therapy Directed Against BCMA and CD19, versus Standard Regimens in Participants with Relapsed Refractory Multiple Myeloma (DURGA-4)
Not yet recruitingCTIS2025-523285-25-00
Target: 38Updated: 2026-04-30
A Phase III, Multicentre Study to Evaluate Consolidation Treatment With AZD0120 Compared With ASCT, in Participants With Newly Diagnosed Multiple Myeloma Who Are Transplant Eligible (DURGA-6).
Not yet recruitingNCT07735637
Start: 2026-08-25End: 2039-11-09Target: 750Updated: 2026-07-30
Study of AZD0120 in Newly Diagnosed Multiple Myeloma Ineligible for ASCT
RecruitingNCT07764978
Start: 2026-06-26End: 2034-05-12Target: 750Updated: 2026-08-14
A Phase III Open-Label, Randomised, Multicentre Study of Consolidation with a Single Administration of AZD0120, a Dual-Targeting Autologous Chimeric Antigen Receptor T-cell (CAR T) Therapy Directed Against BCMA and CD19, Compared with Continuous Standard Therapy in Participants with NDMM Who Are Ineligible to Receive ASCT as Initial Therapy (DURGA-5).
Not yet recruitingCTIS2025-524014-29-00
Target: 234Updated: 2026-09-04