Aybintio 25 mg/ml concentrate for solution for infusion.
Sponsors
Leap Therapeutics Inc., Centre Hospitalier Universitaire De Grenoble, Klinikum der Universitaet Muenchen AöR, Universitaetsklinikum Tuebingen AöR
Conditions
Colorectal CancerGlioblastomanon-resectable hepatocellular carcinoma (HCC)unresectable hepatocellular carcinoma
Phase 2
Ezurpimtrostat autophagy inhibitor in association with Atezolizumab-Bevacizumab in first line treatment of unresectable hepatocellular carcinoma, a phase 2b randomized trial. ABE-LIVER
CompletedCTIS2022-502078-17-00
Start: 2022-12-15End: 2024-03-08Target: 196Updated: 2023-08-22
Randomized Phase 2 Study of DKN-01 Plus FOLFIRI/FOLFOX and Bevacizumab Versus FOLFIRI/FOLFOX and Bevacizumab as Second-line Treatment of Advanced Colorectal Cancer (DeFianCe)
CompletedCTIS2022-501465-40-00
Start: 2023-12-22End: 2025-07-02Target: 25Updated: 2025-06-12
Sequential or up-front triple treatment with durvalumab, tremelimumab and bevacizumab for non-resectable hepatocellular carcinoma (HCC) patients (MONTBLANC)
RecruitingCTIS2024-511439-84-00
Start: 2023-03-30Target: 118Updated: 2025-10-22
PRIDE: A phase IIa, open-label, multicenter study of radiochemotherapy with isotoxic dose escalation and protective VEGF inhibition using bevacizumab in the treatment of patients with first diagnosis of IDH wild-type, MGMT unmethylated glioblastoma
RecruitingCTIS2024-514865-20-00
Start: 2024-04-10Target: 146Updated: 2025-12-09