Axatilimab (INCA034176)
Sponsors
Incyte Corp.
Conditions
Chronic Graft-Versus-Host Diseasechronic graft-versus-host disease
Phase 2
INCA34176-254: A Phase 2, Open-Label, Randomized, Multicenter Study to Evaluate the Safety and Efficacy of Axatilimab in Combination With Ruxolitinib in Participants With Newly Diagnosed Chronic Graft-Versus-Host Disease
RecruitingCTIS2022-502168-19-00
Start: 2024-10-22Target: 70Updated: 2026-01-23
A Phase 2, Randomized, Open-Label Study Of Axatilimab Versus Best Available Therapy in Pediatric Participants With Chronic Graft Versus Host Disease After at Least 2 Prior Lines of Systemic Therapy (AGAVE-256)
Not yet recruitingCTIS2025-521849-25-00
Target: 42Updated: 2026-01-15
Phase 3
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of Axatilimab (INCA034176) and Corticosteroids as Initial Treatment for Chronic Graft-Versus Host Disease
RecruitingCTIS2023-510292-65-00
Start: 2025-02-25Target: 201Updated: 2025-09-18
A Phase 3, Randomized, Open-Label Study of Axatilimab Versus Best Available Therapy in Participants With Chronic Graft-Versus-Host Disease After at Least 2 Prior Lines of Systemic Therapy
RecruitingCTIS2024-518973-32-00
Start: 2025-07-03Target: 283Updated: 2025-10-15