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Avutometinib (VS-6766) + Defactinib (VS-6063)

DRUG2 trials

Sponsors

Verastem, Inc., University of Virginia

Conditions

Locally Advanced Pancreatic CancerLow Grade Serous Ovarian CancerMetastatic Pancreatic CarcinomaOvarian CancerPDAC - Pancreatic Ductal AdenocarcinomaPancreatic Cancer

Phase 1

Neoadjuvant Avutometinib/Defactinib and mFOLFIRINOX Combination Therapy in Pancreatic Adenocarcinoma
Not yet recruitingNCT07824960
University of VirginiaLocally Advanced Pancreatic Cancer, Metastatic Pancreatic Carcinoma, Pancreatic Cancer +1
Start: 2026-10-01End: 2030-04-01Target: 31Updated: 2026-09-17

Phase 2

A Study of Avutometinib + Defactinib in Recurrent Low-Grade Serous Ovarian Cancer in Japanese Patients
Active, not recruitingNCT06682572
Verastem, Inc.Low Grade Serous Ovarian Cancer, Ovarian Cancer
Start: 2024-10-30End: 2027-10-31Updated: 2025-12-17