Avacopan
Sponsors
Amgen Inc., Amgen, Mayo Clinic, Kissei Pharmaceutical Co., Ltd., Robert Spiera, MD
Conditions
ANCA-Associated VasculitisANCA-Associated Vasculitis (AAV)ANCA-associated Vasculitis (AAV)Acne InversaAntineutrophil Cytoplasmic Antibody-associated VasculitisC3 Glomerulopathy (C3G)ElectrocardiographyEnd-Stage Renal Disease (ESRD)
Phase 1
A Study to Assess the Effect of Avacopan at Therapeutic and Supratherapeutic Doses on the QT/QTc Interval in Healthy Participants
CompletedNCT05988034
Start: 2019-11-08End: 2020-03-31Updated: 2023-08-14
A Study to Evaluate the Pharmacokinetics of Avacopan (CCX168) in Participants With Mild or Moderate Hepatic Impairment
CompletedNCT06004934
Start: 2018-04-17End: 2018-09-18Updated: 2023-08-22
Effect of Repeated Oral Doses of Avacopan on the Pharmacokinetics (PK) of a Single Dose of Simvastatin
CompletedNCT06207682
Start: 2022-06-28End: 2022-08-11Updated: 2024-01-17
A Study of Avacopan in Participants With Normal Renal Function and Participants With End-Stage Renal Disease (ESRD)
CompletedNCT06468826
Start: 2024-06-18End: 2024-10-05Updated: 2026-03-25
Phase 2
Controlled Trial Evaluating Avacopan in C3 Glomerulopathy
CompletedNCT03301467
Start: 2017-09-29End: 2021-10-27Updated: 2025-03-13
Evaluation of Safety and Efficacy of Avacopan in Subjects With Moderate to Severe Hidradenitis Suppurativa (AURORA)
CompletedNCT03852472
Start: 2018-12-21End: 2021-03-09Updated: 2025-03-17
Avacopan in Crescentic Immunoglobulin A Nephropathy (IgAN)
RecruitingNCT06676579
Start: 2025-06-09End: 2029-03-02Target: 16Updated: 2025-10-03
TAVNEOS for Otolaryngologic Manifestations of Granulomatosis With Polyangiitis
Not yet recruitingNCT07176546
Start: 2026-07-31End: 2030-10-31Target: 30Updated: 2025-09-19
Phase 3
A Phase 3 Clinical Trial of CCX168 (Avacopan) in Patients With ANCA-Associated Vasculitis
CompletedNCT02994927
Start: 2017-03-15End: 2019-11-01Updated: 2025-03-24
Study to Evaluate Avacopan in Combination With a Rituximab or Cyclophosphamide-containing Regimen, in Children From 6 Years to < 18 Years of Age With AAV.
RecruitingNCT06321601
Start: 2024-10-22End: 2028-09-26Target: 20Updated: 2026-03-06
A Phase 3, Open-label, Uncontrolled Single-arm Study to Evaluate the Efficacy, Pharmacokinetics, and Safety of Avacopan in Combination With a Rituximab or a Cyclophosphamide-containing Regimen in Children from 6 Years to < 18 Years of Age with Active ANCA-associated Vasculitis (AAV)
RecruitingCTIS2024-514779-16-00
Start: 2025-02-11Target: 11Updated: 2026-01-15
Avacopan Added to Standard-of-care Therapy in ANCA-associated Vasculitis With Severe Kidney Involvement
Not yet recruitingNCT07373262
Start: 2026-03-01End: 2030-07-01Target: 130Updated: 2026-01-28