Autologous total tumor mRNA and pp65 full length (fl) lysosomal associated membrane protein (LAMP) mRNA loaded DOTAP liposome vaccine administered intravenously (RNA loaded lipid particles, RNA-LPs)

BIOLOGICAL2 trials

Sponsors

University of Florida

Conditions

Adult GlioblastomaHigh Grade GliomaRecurrent MedulloblastomaWHO Grade III or IV Malignant Glioma

Phase 1

A Study of RNA-lipid Particle (RNA-LP) Vaccines for Newly Diagnosed Pediatric High-Grade Gliomas (pHGG) and Adult Glioblastoma (GBM)

RecruitingNCT04573140

University of FloridaAdult Glioblastoma, High Grade Glioma, WHO Grade III or IV Malignant Glioma

Start: 2021-12-13End: 2029-07-01Target: 28Updated: 2026-06-25

RNA-lipid Particle (RNA-LP) Vaccines for Recurrent/Progressive Medulloblastoma (MB)

RecruitingNCT07492316

University of FloridaRecurrent Medulloblastoma

Start: 2026-04-24End: 2031-03-31Target: 24Updated: 2026-06-29

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