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AUTO1

DRUG6 trials

Sponsors

Autolus Limited

Conditions

B-cell Acute Lymphoblastic Leukemia (B ALL) and Aggressive Mature B-cell Non-Hodgkin Lymphoma (B NHL).Potential malignancy in patients who received treatment with Autolus CAR T cell therapy.Relapsed or Refractory B Cell Acute Lymphoblastic LeukemiaRelapsed or Refractory B Cell Non-Hodgkin LymphomaRelapsed or refractory B cell acute lymphoblastic leukaemiaSystemic Lupus Erythematosus with Active Lupus Nephritis

Phase 1

A Study of CD19 Targeted CAR T Cell Therapy in Adult Patients With Relapsed or Refractory B Cell Acute Lymphoblastic Leukaemia (ALL)
Active, not recruitingNCT04404660
Autolus LimitedRelapsed or Refractory B Cell Acute Lymphoblastic Leukemia
Start: 2020-06-03End: 2029-06-30Updated: 2025-09-09
A Single-Arm, Open-Label, Multicenter, Phase 1b/2 Study Evaluating the Safety and Efficacy of AUTO1 (obecabtagene autoleucel [obe-cel]) in Pediatric Patients with CD19-positive Relapsed/Refractory (R/R) B cell Acute Lymphoblastic Leukemia (B ALL) or R/R Aggressive Mature B Cell Non–Hodgkin Lymphoma (B NHL)
RecruitingCTIS2023-506307-26-00
Autolus LimitedB-cell Acute Lymphoblastic Leukemia (B ALL) and Aggressive Mature B-cell Non-Hodgkin Lymphoma (B NHL).
Start: 2024-05-22Target: 14Updated: 2026-01-09
A Study of CD19 Targeted CAR T Cell Therapy in Pediatric Patients With Relapsed or Refractory B Cell Acute Lymphoblastic Leukemia (B ALL) and Aggressive Mature B-cell Non-Hodgkin Lymphoma (B NHL)
RecruitingNCT06173518
Autolus LimitedRelapsed or Refractory B Cell Acute Lymphoblastic Leukemia, Relapsed or Refractory B Cell Non-Hodgkin Lymphoma
Start: 2023-11-16End: 2027-11-01Target: 30Updated: 2026-03-02
An Open-Label, Multi-Centre, Phase Ib/II Study Evaluating the Safety and Efficacy of AUTO1, a CAR T Cell Treatment Targeting CD19, in Adult Patients with Relapsed or Refractory B Cell Acute Lymphoblastic Leukaemia.
Active, not recruitingCTIS2024-512903-38-00
Autolus LimitedRelapsed or refractory B cell acute lymphoblastic leukaemia
Start: 2021-12-01Target: 17Updated: 2025-12-17

Phase 2

Related Papers

New England Journal of Medicine2024-11-27134 citations