AUTO1
Sponsors
Autolus Limited
Conditions
B-cell Acute Lymphoblastic Leukemia (B ALL) and Aggressive Mature B-cell Non-Hodgkin Lymphoma (B NHL).Potential malignancy in patients who received treatment with Autolus CAR T cell therapy.Relapsed or Refractory B Cell Acute Lymphoblastic LeukemiaRelapsed or Refractory B Cell Non-Hodgkin LymphomaRelapsed or refractory B cell acute lymphoblastic leukaemiaSystemic Lupus Erythematosus with Active Lupus Nephritis
Phase 1
A Study of CD19 Targeted CAR T Cell Therapy in Adult Patients With Relapsed or Refractory B Cell Acute Lymphoblastic Leukaemia (ALL)
Active, not recruitingNCT04404660
Start: 2020-06-03End: 2029-06-30Updated: 2025-09-09
A Single-Arm, Open-Label, Multicenter, Phase 1b/2 Study Evaluating the Safety and Efficacy of AUTO1 (obecabtagene autoleucel [obe-cel]) in Pediatric Patients with CD19-positive Relapsed/Refractory (R/R) B cell Acute Lymphoblastic Leukemia (B ALL) or R/R Aggressive Mature B Cell Non–Hodgkin Lymphoma (B NHL)
RecruitingCTIS2023-506307-26-00
Start: 2024-05-22Target: 14Updated: 2026-01-09
A Study of CD19 Targeted CAR T Cell Therapy in Pediatric Patients With Relapsed or Refractory B Cell Acute Lymphoblastic Leukemia (B ALL) and Aggressive Mature B-cell Non-Hodgkin Lymphoma (B NHL)
RecruitingNCT06173518
Start: 2023-11-16End: 2027-11-01Target: 30Updated: 2026-03-02
An Open-Label, Multi-Centre, Phase Ib/II Study Evaluating the Safety and Efficacy of AUTO1, a CAR T Cell Treatment Targeting CD19, in Adult Patients with Relapsed or Refractory B Cell Acute Lymphoblastic Leukaemia.
Active, not recruitingCTIS2024-512903-38-00
Start: 2021-12-01Target: 17Updated: 2025-12-17
Phase 2
Long-term follow-up of patients previously treated with autologous T cells genetically modified with viral vectors.
RecruitingCTIS2024-511684-28-00
Start: 2025-09-01Target: 21Updated: 2025-06-26
A SINGLE-ARM, OPEN-LABEL, PHASE II STUDY TO DETERMINE THE SAFETY AND EFFICACY OF OBECABTAGENE AUTOLEUCEL (OBE-CEL) IN PARTICIPANTS WITH SEVERE, REFRACTORY SYSTEMIC LUPUS ERYTHEMATOSUS WITH ACTIVE LUPUS NEPHRITIS
Not yet recruitingCTIS2024-519941-32-00
Target: 3Updated: 2025-11-20