Atovaquone-proguanil

DRUG6 trials

Sponsors

National Institute of Allergy and Infectious Diseases (NIAID), Novartis, Armed Forces Research Institute of Medical Sciences, Thailand, Radboud University Medical Center, U.S. Army Medical Research and Development Command

Conditions

FalciparumMalariaMalaria InfectionPlasmodium FalciparumPlasmodium Falciparum Infection

Phase 1

Controlled Human Malaria Infection Model for Evaluation of Transmission-Blocking Interventions - Study 1

CompletedNCT02836002

Radboud University Medical CenterMalaria

Start: 2016-06-30End: 2017-06-29Updated: 2018-03-23

Phase 2

Efficacy, Safety, and PK of M5717 in Combination With Pyronaridine as Chemoprevention in Adults and Adolescents With Asymptomatic Plasmodium Falciparum Infection (CAPTURE-2)

CompletedNCT05974267

Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, GermanyMalaria Infection

Start: 2023-11-28End: 2024-12-29Updated: 2026-02-06

Phase 3

Chloroquine Alone or in Combination for Malaria in Children in Malawi

CompletedNCT00379821

National Institute of Allergy and Infectious Diseases (NIAID)Plasmodium Falciparum Infection

Start: 2007-02-28End: 2012-09-30Updated: 2014-08-11

Phase 4

Evaluation of Potential Effect of Artemether - Lumefantrine and Malaria Drugs on Auditory Function

CompletedNCT00444106

NovartisFalciparum, Malaria

Start: 2007-05-31End: 2008-11-30Updated: 2011-04-05

The ASAP Study - Therapeutic Efficacy of Atovaquone-proguanil vs. Artesunate-atovaquone-proguanil in Cambodia

Armed Forces Research Institute of Medical Sciences, ThailandMalaria

Start: 2014-12-31End: 2021-12-31Updated: 2021-03-02

Unknown Phase

A Clinical Trial to Evaluate Plasmodium Falciparum 7G8 and NF54 Challenge Strains (PfSPZ) in a Head-to-head Comparative Study - (ECG-CHMI)

WithdrawnNCT04203186

U.S. Army Medical Research and Development CommandPlasmodium Falciparum

Start: 2020-03-31End: 2021-09-30Updated: 2020-05-08

Related Papers

The XN-30 hematology analyzer for rapid sensitive detection of malaria: a diagnostic accuracy study.

2019-05-3125 citations

A randomized feasibility trial comparing four antimalarial drug regimens to induce Plasmodium falciparum gametocytemia in the controlled human malaria infection model

eLife2018-02-2667 citations

A longitudinal trial comparing chloroquine as monotherapy or in combination with artesunate, azithromycin or atovaquone-proguanil to treat malaria.

2012-08-1727 citations