ataciguat (HMR1766)

DRUG3 trials

Sponsors

Sanofi, Mayo Clinic

Conditions

Aortic Valve StenosisIntermittent ClaudicationPain

Phase 2

Efficacy and Safety of HMR1766 in Patients With Fontaine Stage II Peripheral Arterial Disease

CompletedNCT00443287

SanofiIntermittent Claudication

Start: 2007-02-28End: 2008-10-31Updated: 2018-05-17

Efficacy and Safety Study of Ataciguat Versus Placebo in Patients With Neuropathic Pain

CompletedNCT00799656

Start: 2008-11-30End: 2009-09-30Updated: 2011-04-01

A Study Evaluating the Effects of Ataciguat (HMR1766) on Aortic Valve Calcification

CompletedNCT02481258

Mayo ClinicAortic Valve Stenosis

Start: 2015-06-30End: 2019-12-01Updated: 2021-01-22

Related Papers

Abstract 4367120: Impact of Aortic Valve Calcification on Functional Valve Area and Cardiac Structure and Function in a Phase 2 Trial of Ataciguat

Circulation2025-11-03

Reactivation of Oxidized Soluble Guanylate Cyclase as a Novel Treatment Strategy to Slow Progression of Calcific Aortic Valve Stenosis: Preclinical and Randomized Clinical Trials to Assess Safety and Efficacy

Circulation2025-02-2412 citations