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Asparaginase Erwinia chrysanthemi

DRUG11 trials

Sponsors

Jazz Pharmaceuticals, Children's Oncology Group, St. Jude Children's Research Hospital, Incyte Corporation, National Cancer Institute (NCI)

Conditions

Acute Leukemia of Ambiguous LineageAcute Lymphoblastic LeukemiaAcute Myeloid LeukemiaB Acute Lymphoblastic LeukemiaB Acute Lymphoblastic Leukemia, Philadelphia Chromosome NegativeB Lymphoblastic LymphomaDown SyndromeLeukemia

Phase 1

Phase 2

A Study of Erwinaze Administered Intravenously in Patients Who Had an Allergy to Frontline Asparaginase Therapy
CompletedNCT01643408
Jazz PharmaceuticalsAcute Lymphoblastic Leukemia, Lymphoblastic Lymphoma
Start: 2012-11-30End: 2013-12-31Updated: 2021-06-23
A Phase 2 Study of Ruxolitinib With Chemotherapy in Children With Acute Lymphoblastic Leukemia
CompletedNCT02723994
Incyte CorporationLeukemia
Start: 2016-09-30End: 2026-03-03Updated: 2026-03-11
Inotuzumab Ozogamicin in Treating Younger Patients With B-Lymphoblastic Lymphoma or Relapsed or Refractory CD22 Positive B Acute Lymphoblastic Leukemia
RecruitingNCT02981628
Children's Oncology GroupRecurrent B Acute Lymphoblastic Leukemia, Recurrent B Lymphoblastic Lymphoma, Refractory B Acute Lymphoblastic Leukemia +1
Start: 2017-06-19End: 2026-12-31Target: 80Updated: 2026-02-23
Testing the Addition of the Anti-cancer Drug Venetoclax and/or the Anti-cancer Immunotherapy Blinatumomab to the Usual Chemotherapy Treatment for Infants With Newly Diagnosed KMT2A-rearranged or KMT2A-non-rearranged Leukemia
RecruitingNCT06317662
National Cancer Institute (NCI)Acute Leukemia of Ambiguous Lineage, B Acute Lymphoblastic Leukemia
Start: 2025-06-05End: 2028-12-31Target: 153Updated: 2026-04-03
Etoposide, Prednisone, Vincristine, Cyclophosphamide, and Doxorubicin (DA-EPOCH) With or Without Rituximab Plus Recombinant Erwinia Asparaginase (JZP458) for the Treatment of Newly Diagnosed Ph Negative B-Acute Lymphoblastic Leukemia or T Acute Lymphoblastic Leukemia
RecruitingNCT06738368
University of WashingtonB Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative, T Acute Lymphoblastic Leukemia
Start: 2026-04-01End: 2028-07-30Target: 30Updated: 2026-03-13
Asparaginase Erwinia Chrysanthemi With Chemotherapy for the Treatment of High-Risk Adults With Newly Diagnosed Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma
RecruitingNCT06918431
City of Hope Medical CenterB Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative, Lymphoblastic Lymphoma
Start: 2025-10-10End: 2029-03-30Target: 53Updated: 2026-03-17

Phase 3

Related Papers

New England Journal of Medicine2024-12-07122 citations

9 more papers not shown