Asparaginase Erwinia chrysanthemi
Sponsors
Jazz Pharmaceuticals, Children's Oncology Group, St. Jude Children's Research Hospital, Incyte Corporation, National Cancer Institute (NCI)
Conditions
Acute Leukemia of Ambiguous LineageAcute Lymphoblastic LeukemiaAcute Myeloid LeukemiaB Acute Lymphoblastic LeukemiaB Acute Lymphoblastic Leukemia, Philadelphia Chromosome NegativeB Lymphoblastic LymphomaDown SyndromeLeukemia
Phase 1
Total Therapy for Infants With Acute Lymphoblastic Leukemia (ALL) I
Active, not recruitingNCT02553460
Start: 2016-01-29End: 2031-10-31Updated: 2025-12-10
Recombinant Erwinia Asparaginase and Venetoclax in Combination With Blinatumomab for the Treatment of Relapsed or Refractory CD19 Positive B-cell Acute Lymphoblastic Leukemia
Not yet recruitingNCT07133997
Start: 2026-06-01End: 2027-05-08Target: 26Updated: 2026-03-13
Phase 2
A Study of Erwinaze Administered Intravenously in Patients Who Had an Allergy to Frontline Asparaginase Therapy
CompletedNCT01643408
Start: 2012-11-30End: 2013-12-31Updated: 2021-06-23
A Phase 2 Study of Ruxolitinib With Chemotherapy in Children With Acute Lymphoblastic Leukemia
CompletedNCT02723994
Start: 2016-09-30End: 2026-03-03Updated: 2026-03-11
Inotuzumab Ozogamicin in Treating Younger Patients With B-Lymphoblastic Lymphoma or Relapsed or Refractory CD22 Positive B Acute Lymphoblastic Leukemia
RecruitingNCT02981628
Start: 2017-06-19End: 2026-12-31Target: 80Updated: 2026-02-23
Testing the Addition of the Anti-cancer Drug Venetoclax and/or the Anti-cancer Immunotherapy Blinatumomab to the Usual Chemotherapy Treatment for Infants With Newly Diagnosed KMT2A-rearranged or KMT2A-non-rearranged Leukemia
RecruitingNCT06317662
Start: 2025-06-05End: 2028-12-31Target: 153Updated: 2026-04-03
Etoposide, Prednisone, Vincristine, Cyclophosphamide, and Doxorubicin (DA-EPOCH) With or Without Rituximab Plus Recombinant Erwinia Asparaginase (JZP458) for the Treatment of Newly Diagnosed Ph Negative B-Acute Lymphoblastic Leukemia or T Acute Lymphoblastic Leukemia
RecruitingNCT06738368
Start: 2026-04-01End: 2028-07-30Target: 30Updated: 2026-03-13
Asparaginase Erwinia Chrysanthemi With Chemotherapy for the Treatment of High-Risk Adults With Newly Diagnosed Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma
RecruitingNCT06918431
Start: 2025-10-10End: 2029-03-30Target: 53Updated: 2026-03-17
Phase 3
Response-Based Chemotherapy in Treating Newly Diagnosed Acute Myeloid Leukemia or Myelodysplastic Syndrome in Younger Patients With Down Syndrome
Active, not recruitingNCT02521493
Start: 2015-12-23End: 2026-06-30Updated: 2025-08-01
A Study to Investigate Blinatumomab in Combination With Chemotherapy in Patients With Newly Diagnosed B-Lymphoblastic Leukemia
Active, not recruitingNCT03914625
Start: 2019-07-03End: 2027-09-30Target: 6720Updated: 2026-04-03
A Study to Compare Standard Chemotherapy to Therapy With CPX-351 and/or Gilteritinib for Patients With Newly Diagnosed AML With or Without FLT3 Mutations
RecruitingNCT04293562
Start: 2020-07-21End: 2029-06-30Target: 1186Updated: 2026-02-24
Related Papers
9 more papers not shown