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Artificial Cerebrospinal Fluid (aCSF) for injection
DRUG
2 trials
Sponsors
Ionis Pharmaceuticals Inc.
Conditions
Alexander Disease
Amyotrophic Lateral Sclerosis with Fused in Sarcoma mutations
Phase 1
ION373-CS1: A Phase 1-3, Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of Intrathecally Administered ION373 in Patients with Alexander Disease
Active, not recruiting
CTIS2024-510603-11-00
Ionis Pharmaceuticals Inc.
Alexander Disease
Start: 2021-04-08
Target: 15
Updated: 2025-07-24
Phase 2
ION363-CS1: A Phase 1-3 Study to Evaluate the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of Intrathecally Administered ION363 in Amyotrophic Lateral Sclerosis Patients with Fused in Sarcoma Mutations (FUS-ALS)
Active, not recruiting
CTIS2024-512163-31-00
Ionis Pharmaceuticals Inc.
Amyotrophic Lateral Sclerosis with Fused in Sarcoma mutations
Start: 2022-01-26
Target: 57
Updated: 2025-10-27