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Artesunate-mefloquine

DRUG5 trials

Sponsors

Albert Schweitzer Hospital, Novartis, Institute of Tropical Medicine, Belgium, University of Oxford, Menzies School of Health Research

Conditions

FalciparumMalariaMalaria in PregnancyUncomplicated Plasmodium Knowlesi Malaria

Phase 2

Efficacy, Safety and Pharmacokinetic of ArtequinTM P. Falciparum Malaria
CompletedNCT00243737
Albert Schweitzer HospitalMalaria
Start: 2005-10-31End: 2006-04-30Target: 70Updated: 2013-01-24

Phase 3

Safe and Efficacious Artemisinin-based Combination Treatments for African Pregnant Women With Malaria
CompletedNCT00852423
Institute of Tropical Medicine, BelgiumMalaria in Pregnancy
Start: 2010-06-30End: 2015-04-30Updated: 2016-03-14
Randomised Trial of 3 Artemisinin Combination Therapy for Malaria in Pregnancy
CompletedNCT01054248
University of OxfordMalaria
Start: 2010-02-16End: 2016-09-30Updated: 2022-03-25
P. Knowlesi Trial of Artesunate-mefloquine Versus Chloroquine
CompletedNCT01708876
Menzies School of Health ResearchUncomplicated Plasmodium Knowlesi Malaria
Start: 2012-10-31End: 2014-12-31Target: 250Updated: 2015-04-09

Phase 4

Evaluation of Potential Effect of Artemether - Lumefantrine and Malaria Drugs on Auditory Function
CompletedNCT00444106
NovartisFalciparum, Malaria
Start: 2007-05-31End: 2008-11-30Updated: 2011-04-05

Related Papers

Population pharmacokinetics of amodiaquine and piperaquine in African pregnant women with uncomplicated <i>Plasmodium falciparum</i> infections
CPT Pharmacometrics & Systems Pharmacology2024-09-034 citations
Comparison of lumefantrine, mefloquine, and piperaquine concentrations between capillary plasma and venous plasma samples in pregnant women with uncomplicated falciparum and vivax malaria
Antimicrobial Agents and Chemotherapy2024-04-103 citations
Joint modelling of multivariate longitudinal clinical laboratory safety outcomes, concomitant medication and clinical adverse events: application to artemisinin-based treatment during pregnancy clinical trial
BMC Medical Research Methodology2021-10-092 citations
A randomized controlled trial of dihydroartemisinin-piperaquine, artesunate-mefloquine and extended artemether-lumefantrine treatments for malaria in pregnancy on the Thailand-Myanmar border.
2021-06-1016 citations
Artemisinin-based combination therapy during pregnancy: outcome of pregnancy and infant mortality: a cohort study
Malaria Journal2019-03-2817 citations
Efficacy of Artesunate-mefloquine for Chloroquine-resistant<i>Plasmodium vivax</i>Malaria in Malaysia: An Open-label, Randomized, Controlled Trial
Clinical Infectious Diseases2016-04-2251 citations
Four Artemisinin-Based Treatments in African Pregnant Women with Malaria
New England Journal of Medicine2016-03-10102 citations
Artesunate-mefloquine versus chloroquine for treatment of uncomplicated Plasmodium knowlesi malaria in Malaysia (ACT KNOW): an open-label, randomised controlled trial.
2015-11-1954 citations
Ex vivo anti-malarial drug susceptibility of Plasmodium falciparum isolates from pregnant women in an area of highly seasonal transmission in Burkina Faso
Malaria Journal2015-06-186 citations
A study protocol for a randomised open-label clinical trial of artesunate-mefloquine versus chloroquine in patients with non-severe <i>Plasmodium knowlesi</i> malaria in Sabah, Malaysia (ACT KNOW trial)
BMJ Open2014-08-0116 citations