Artemether-lumefantrine combination

DRUG16 trials

Conditions

AnaemiaAsymptomatic MalariaHIVMalariaMalaria, FalciparumParasitologically Confirmed; MalarialPlasmodium FalciparumPlasmodium Vivax Infection

Phase 1

Trial of Artemether-Lumefantrine Alone and in Combination With Ivermectin to Reduce Post-Treatment Malaria Transmission

CompletedNCT01603251

London School of Hygiene and Tropical MedicineMalaria

Start: 2013-01-31End: 2013-04-30Updated: 2013-04-18

Dolutegravir Interactions With Artemisinin-based Combination Therapies

CompletedNCT02242799

University of LiverpoolHIV, Malaria

Start: 2015-06-30End: 2016-09-30Updated: 2016-10-05

Phase 2

Low Dose Primaquine for Clearance of Gametocytes

CompletedNCT01935882

London School of Hygiene and Tropical MedicineAsymptomatic Malaria, Malaria, Plasmodium Falciparum

Start: 2013-09-30End: 2015-07-31Updated: 2015-09-02

Phase 3

Artemisinin-Based Antimalarial Combinations and Clinical Response in Cameroon

CompletedNCT01845701

University of Yaounde 1Malaria

Start: 2010-03-31End: 2015-04-30Updated: 2018-09-26

Treatment Efficacy and Malaria TRANSmission After Artemisinin Combination Therapy 2 (TRANSACT2)

CompletedNCT01939886

London School of Hygiene and Tropical MedicineMalaria

Start: 2013-04-30End: 2013-11-30Updated: 2013-11-28

P. Knowlesi Trial of Artemether-lumefantrine vs Chloroquine

CompletedNCT02001012

Menzies School of Health ResearchUncomplicated Knowlesi Malaria

Start: 2014-01-31End: 2015-03-31Updated: 2017-07-07

Pyronaridine-artesunate and Artemether-lumefantrine for the Treatment of Paediatric Malaria

CompletedNCT02411994

Royal Tropical InstituteMalaria

Start: 2015-10-31End: 2017-08-31Updated: 2017-11-27

Phase 4

Safety and Effectiveness of Artemisinin-based Combination Therapies (ACTs) With Repeated Treatments for Uncomplicated Falciparum Malaria Over a Three-year Period

NCT01038063

Liverpool School of Tropical MedicineMalaria

Start: 2010-10-31End: 2013-09-30Target: 1200Updated: 2010-12-09

Artemether-Lumefantrine Clinical Effectiveness Study

CompletedNCT01599000

Papua New Guinea Institute of Medical ResearchParasitologically Confirmed; Malarial

Start: 2011-03-31End: 2012-07-31Updated: 2012-08-16

Seasonal Malaria Chemoprevention Versus Home Management of Malaria in Children Under 5 Years in Ghana

CompletedNCT01651416

Centre for Global Health Research, GhanaAnaemia, Malaria

Start: 2012-07-31End: 2013-07-31Updated: 2015-09-18

Ethiopia Antimalarial in Vivo Efficacy Study 2012

CompletedNCT01680406

Centers for Disease Control and PreventionPlasmodium Vivax Infection

Start: 2012-10-31End: 2014-12-31Updated: 2017-01-19

A Study to Assess Safety of Current Standard Malaria Treatment and an Assessment of G6PD Status in South-east Bangladesh

CompletedNCT02389374

Menzies School of Health ResearchMalaria

Start: 2014-08-31End: 2015-03-31Updated: 2024-03-13

Unknown Phase

Assessment of Use of Rapid Diagnostic Testing in the Context of Home Management With ACTs

CompletedNCT00720811

Mbarara University of Science and TechnologyMalaria, Pneumonia

Start: 2009-10-31End: 2012-01-31Updated: 2012-03-16

Efficacy of Artemether-lumefantrine, Artesunate-amodiaquine and Dihydroartemisinin-piperaquine for the Treatment of Uncomplicated Plasmodium Falciparum Malaria in Malawi

CompletedNCT01326754

Centers for Disease Control and PreventionMalaria, Falciparum

Start: 2011-08-31End: 2012-06-30Updated: 2013-02-25

Reducing the Burden of Malaria by Targeting Hotspots of Malaria Transmission

CompletedNCT01575613

Radboud University Medical CenterMalaria

Start: 2012-04-30End: 2012-11-30Updated: 2012-11-27

Artemether-lumefantrine for Treatment of P. Falciparum Malaria in Brazil

CompletedNCT02600767

Centers for Disease Control and PreventionMalaria

Start: 2015-12-31End: 2016-12-31Updated: 2017-10-09

2025-08-057 citations

Drug Interactions between Dolutegravir and Artemether-Lumefantrine or Artesunate-Amodiaquine.

2019-01-2921 citations

Plasmodium falciparum gametocyte dynamics after pyronaridine-artesunate or artemether-lumefantrine treatment.

2018-06-0413 citations

Pyronaridine-artesunate and artemether-lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in Kenyan children: a randomized controlled non-inferiority trial.

2018-05-1523 citations

Artemether-Lumefantrine Versus Chloroquine for the Treatment of Uncomplicated Plasmodium knowlesi Malaria: An Open-Label Randomized Controlled Trial CAN KNOW

Clinical Infectious Diseases2017-08-2929 citations

Molecular analysis demonstrates high prevalence of chloroquine resistance but no evidence of artemisinin resistance in Plasmodium falciparum in the Chittagong Hill Tracts of Bangladesh.

2017-08-158 citations

Comparison of artemether-lumefantrine and chloroquine with and without primaquine for the treatment of Plasmodium vivax infection in Ethiopia: A randomized controlled trial

PLoS Medicine2017-05-16102 citations

Age, Weight, and <i>CYP2D6</i> Genotype Are Major Determinants of Primaquine Pharmacokinetics in African Children

Antimicrobial Agents and Chemotherapy2017-03-1460 citations

G6PD Deficiency and Antimalarial Efficacy for Uncomplicated Malaria in Bangladesh: A Prospective Observational Study

PLoS ONE2016-04-2946 citations

The Impact of Hotspot-Targeted Interventions on Malaria Transmission in Rachuonyo South District in the Western Kenyan Highlands: A Cluster-Randomized Controlled Trial

PLoS Medicine2016-04-12134 citations

Single low dose primaquine to reduce gametocyte carriage and Plasmodium falciparum transmission after artemether-lumefantrine in children with asymptomatic infection: a randomised, double-blind, placebo-controlled trial.

2016-03-0860 citations

Randomized non-inferiority and safety trial of dihydroartemisin-piperaquine and artesunate-amodiaquine versus artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in Cameroonian children

Malaria Journal2015-01-2741 citations

The impact of hotspot-targeted interventions on malaria transmission: study protocol for a cluster-randomized controlled trial.

2013-02-0252 citations