Arm B

DRUG18 trials

Sponsors

Boehringer Ingelheim, Fudan University, National University Hospital, Singapore, James J Lee, Heidelberg University

Conditions

Acute Myeloid LeukemiaBreast CancerCancerEsophageal CancerHIV/AIDSHIV/AIDS PaediatricsIrritable Bowel Syndrome With Constipation (IBS-C)Leprosy, Buruli Ulcer and Lymphatic Filariasis Mental and Behavioural Disorders Skin and Connective Tissue Diseases

Phase 1

Phase I Study of BI 831266 in Patients With Advanced Solid Tumours

CompletedNCT00756223

Boehringer IngelheimNeoplasms

Start: 2008-11-30Updated: 2013-11-21

Single-fraction IMRT Versus External Beam Radiotherapy for Patients With Spine Bone Metastases

Heidelberg UniversityPain

Start: 2014-12-31End: 2016-12-31Target: 60Updated: 2015-02-09

A HR20031 BE Study on Healthy Subjects

CompletedNCT05682495

Shandong Suncadia Medicine Co., Ltd.Type 2 Diabetes

Start: 2023-01-31End: 2023-04-04Updated: 2023-04-07

Phase 2

Docetaxel and Cisplatin Chemotherapy With or Without High Dose Proton Pump Inhibitor in Metastatic Breast Cancer

CompletedNCT01069081

Fudan UniversityBreast Cancer, Metastasis, Neoplasm

Start: 2009-08-31End: 2012-02-29Updated: 2015-03-06

Randomized Study of Doxorubicin and Cyclophosphamide With or Without Intermittent Sunitinib in the First-line Treatment of Locally Advanced or Metastatic Breast Cancer Patients With Measurable Primary Breast Tumor

National University Hospital, SingaporeBreast Cancer

Start: 2010-08-31End: 2017-12-31Target: 73Updated: 2016-06-22

A Phase II Study of Ziv-aflibercept in Combination With Capecitabine/Oxaliplatin (XELOX) Chemotherapy in the Front-Line Treatment of Patients With Metastatic Colorectal Cancer

WithdrawnNCT02079220

James J LeeMetastatic Colorectal Cancer

Start: 2014-03-31End: 2018-03-31Updated: 2017-07-31

Phase II Randomized Trial of Carboplatin+Pemetrexed+Bevacizumab+/- Atezolizumab in Stage IV NSCLC

Active, not recruitingNCT03786692

Fox Chase Cancer CenterNon-Small Cell Carcinoma of Lung, TNM Stage 4

Start: 2019-09-04End: 2028-01-01Updated: 2026-05-22

RecruitingPACTR202211865409139

University of Cape TownTuberculosis Respiratory

Start: 2020-07-01Target: 342Updated: 2026-08-03

Tislelizumab Plus Concurrent Chemoradiation in Older With ESCC

RecruitingNCT06061146

Tianjin Medical University Cancer Institute and HospitalEsophageal Cancer

Start: 2023-10-05End: 2026-10-01Target: 136Updated: 2023-12-26

Platform Assessing Regimens And Durations In a Global Multisite Consortium for TB [PARADIGM4TB (UNITE4TB – 01)]

Active, not recruitingPACTR202403493915530

University College LondonTuberculosis

Start: 2024-04-15Target: 2500Updated: 2026-08-03

Phase 3

A Study to Evaluate Patient Preference for Home Administration of Fixed-Dose Combination of Pertuzumab and Trastuzumab for Subcutaneous Administration in Participants With Early or Locally Advanced/Inflammatory HER2-Positive Breast Cancer (ProHer)

RecruitingPACTR202211579014330

Hoffmann La RocheCancer

Start: 2022-07-05Target: 330Updated: 2026-08-03

Unknown Phase

Strategies to optimize antiretroviral therapy services for maternal & child health: the MCH-ART study

RecruitingPACTR201411000884278

Columbia UniversityHIV/AIDS

Start: 2013-04-01Target: 1600Updated: 2026-08-03

Using RCT to Increase Completion Rates of the Health Assessment Questionnaire.

CompletedNCT03435484

NYU Langone HealthPatient-reported Outcomes

Start: 2018-02-07End: 2019-05-31Updated: 2022-10-10

Efficacy and Safety, Tolerability of GA-AT0119 in IBS-C

Devintec SaglIrritable Bowel Syndrome With Constipation (IBS-C)

Start: 2021-11-01End: 2022-08-31Target: 60Updated: 2022-02-15

Monthly versus three doses malaria chemoprophylaxis in pregnancy at Lautech Teaching Hospital Osogbo, a randomised controlled study

Active, not recruitingPACTR202304768950531

AYODELE KABIR ALAOMalaria MALARIA IN PREGNANCY

Start: 2021-11-01Target: 242Updated: 2026-08-03

Active, not recruitingPACTR202404852537141

EFFECT HOPE CANADALeprosy, Buruli Ulcer and Lymphatic Filariasis Mental and Behavioural Disorders Skin and Connective Tissue Diseases

Start: 2022-10-01Target: 200Updated: 2026-08-03

Neonatal HIV Early Infant Diagnosis (EID) Versus Standard of Care EID- Long Term Impact on inFant hEalth (LIFE) (LIFE)

Active, not recruitingPACTR202502499975779

Medical Centre of the University of MunichHIV/AIDS Paediatrics

Start: 2019-10-13Target: 6000Updated: 2026-08-03

ONC-LEUK-2406: The Impact of Systematic Financial Navigation in Acute Myeloid Leukemia

RecruitingNCT06945042

Wake Forest University Health SciencesAcute Myeloid Leukemia

Start: 2025-06-27End: 2028-05-01Target: 120Updated: 2026-07-23

Related Papers

Tislelizumab plus concurrent chemoradiotherapy versus concurrent chemoradiotherapy for elderly patients with inoperable locally advanced esophageal squamous cell carcinoma: a multicenter, randomized, parallel-controlled, phase II clinical trial

BMC Cancer2025-02-252 citations

Reassessing the Significance of Mycobacterium in Neglected Tropical Diseases: A Study Protocol in Nigeria

International Journal of Mycobacteriology2024-10-01

Tislelizumab plus concurrent chemoradiotherapy versus concurrent chemoradiotherapy for elderly patients with inoperable locally advanced esophageal squamous cell carcinoma: A multicenter, randomized, parallel-controlled, phase II clinical trial.

Journal of Clinical Oncology2024-06-01

Phase II Randomized Trial of Carboplatin, Pemetrexed, and Bevacizumab With and Without Atezolizumab in Stage IV Nonsquamous Non-Small-Cell Lung Cancer Patients Who Harbor a Sensitizing EGFR Mutation or Have Never Smoked.

2023-05-111 citations

Phase II trial of atezolizumab (A) + carboplatin (C) + pemetrexed (P) + bevacizumab (B) in pts with stage IV non-squamous non-small cell lung cancer (NSq-NSCLC): Big Ten Cancer Research Consortium Study LUN 17-139.

Journal of Clinical Oncology2021-05-204 citations

Phase II randomized trial of carboplatin + pemetrexed + bevacizumab, +/- atezolizumab in stage IV non-squamous non-small lung cancer (NSCLC) patients who harbor a sensitizing EGFR mutation or have never smoked.

Journal of Clinical Oncology2020-05-201 citations

Local response and pathologic fractures following stereotactic body radiotherapy versus three-dimensional conformal radiotherapy for spinal metastases - a randomized controlled trial.

2018-08-3127 citations

Quality of Life Following Stereotactic Body Radiotherapy <i>Versus</i> Three-Dimensional Conformal Radiotherapy for Vertebral Metastases: Secondary Analysis of an Exploratory Phase II Randomized Trial.

2018-08-0125 citations

Randomized phase II trial evaluating pain response in patients with spinal metastases following stereotactic body radiotherapy versus three-dimensional conformal radiotherapy.

2018-05-26160 citations

Genomic predictors of neoadjuvant chemotherapy (NACT) response in breast cancer (BC).

Journal of Clinical Oncology2017-05-201 citations

Intermittent high dose proton pump inhibitor enhances the antitumor effects of chemotherapy in metastatic breast cancer.

2015-08-22120 citations

High-dose single-fraction IMRT versus fractionated external beam radiotherapy for patients with spinal bone metastases: study protocol for a randomized controlled trial.

2015-06-0911 citations

A phase 1 dose escalation study of BI 831266, an inhibitor of Aurora kinase B, in patients with advanced solid tumors

Investigational New Drugs2014-12-2217 citations

Effect of low-dose, short-course sunitinib (Su) on tumor vasculature and tumor blood flow for enhancement of chemotherapy efficacy in breast cancer.

Journal of Clinical Oncology2014-05-20