Apelin

DRUG6 trials

Sponsors

University of Edinburgh, Golden Jubilee National Hospital, University Hospital, Toulouse, Cambridge University Hospitals NHS Foundation Trust

Conditions

Cardiovascular DiseasesDiabetesHealthyHeart DiseaseHeart FailurePulmonary Arterial HypertensionType 2 Diabetes MellitusVasodilatation

Phase 1

Effect of Apelin on Insulin Sensitivity: Proof of Concept in Healthy Volunteers

CompletedNCT02033473

University Hospital, ToulouseHealthy

Start: 2014-01-31End: 2014-10-31Updated: 2019-07-12

Effect of Apelin on Insulin Sensitivity in Type 2 Diabetic Volunteers

CompletedNCT02724566

University Hospital, ToulouseDiabetes

Start: 2016-05-31End: 2017-04-30Updated: 2025-12-10

Phase 2

A Series of Pilot Studies to Evaluate the haemoDynamic and mEtabolic Effects oF apelIn aNd rElaxin

Active, not recruitingNCT03449251

Cambridge University Hospitals NHS Foundation TrustCardiovascular Diseases, Type 2 Diabetes Mellitus

Start: 2018-03-28End: 2025-09-30Target: 170Updated: 2024-02-07

Unknown Phase

Investigating Systemic and Local Vascular Responses to Apelin in the Context of Renin-angiotensin Upregulation

CompletedNCT00901719

University of EdinburghHeart Disease, Heart Failure, Vasodilatation

Start: 2010-04-30End: 2010-05-31Target: 12Updated: 2010-08-10

Investigating the Inotropic Potential of Apelin

CompletedNCT01179061

University of EdinburghHeart Failure

Start: 2010-08-31End: 2012-07-31Updated: 2024-05-09

Effects of Apelin on the Lung Circulation in Pulmonary Hypertension

Golden Jubilee National HospitalHeart Failure, Pulmonary Arterial Hypertension

Start: 2012-01-31End: 2014-01-31Target: 63Updated: 2013-07-15

Related Papers

Short-Term Hemodynamic Effects of Apelin in Patients With Pulmonary Arterial Hypertension.

2018-03-2834 citations

Sustained cardiovascular actions of APJ agonism during renin-angiotensin system activation and in patients with heart failure.

2013-03-2196 citations