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Antithymocyte globulin (ATG)

DRUG8 trials

Sponsors

Office of Rare Diseases (ORD), M.D. Anderson Cancer Center, H. Lee Moffitt Cancer Center and Research Institute, University of Chicago, Medical College of Wisconsin

Conditions

Graft Versus Host DiseaseHematologic MalignanciesHematological DiseaseLeukemiaMyelodysplastic SyndromeSevere Aplastic AnemiaTransplant RejectionType 1 Diabetes Mellitus

Phase 1

Giving Chemotherapy for a Shortened Amount of Time Before a Stem Cell Transplantation
Active, not recruitingNCT04098393
Memorial Sloan Kettering Cancer CenterHematologic Malignancies
Start: 2019-09-18End: 2026-09-30Target: 39Updated: 2025-06-29

Phase 2

Effects of Antithymocyte Globulin in Adults With Myelodysplastic Syndrome
NCT00466843
Office of Rare Diseases (ORD)Myelodysplastic Syndrome
Start: 2007-04-30End: 2010-02-28Target: 54Updated: 2009-06-02
Imatinib Mesylate, Busulfan, Fludarabine, and Antithymocyte Globulin for CML Patients
TerminatedNCT00499889
M.D. Anderson Cancer CenterLeukemia
Start: 2003-02-28End: 2009-11-30Updated: 2012-04-23
Visilizumab for the Prevention of Graft-versus-Host Disease After Allogeneic Hematopoietic Cell Transplantation
TerminatedNCT00720629
H. Lee Moffitt Cancer Center and Research InstituteGraft Versus Host Disease
Start: 2007-12-31End: 2013-12-31Updated: 2014-07-18
Cord Blood Transplantation for Patients With Cancer
TerminatedNCT01359254
University of ChicagoHematological Disease
Start: 2010-04-30End: 2012-06-30Updated: 2015-04-30
Optimizing Haploidentical Aplastic Anemia Transplantation (BMT CTN 1502)
CompletedNCT02918292
Medical College of WisconsinSevere Aplastic Anemia
Start: 2017-07-03End: 2021-08-17Updated: 2026-03-31
BIVV020 (SAR445088) in Prevention and Treatment of Antibody-mediated Rejection (AMR)
Active, not recruitingNCT05156710
SanofiTransplant Rejection
Start: 2022-06-09End: 2026-10-26Updated: 2026-02-24
Platform Trial to Delay Stage 3 Diabetes: Comparing Teplizumab With ATG
Not yet recruitingNCT07216391
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)Type 1 Diabetes Mellitus
Start: 2026-04-15End: 2030-05-30Target: 60Updated: 2026-02-20

Related Papers

Trial in Progress: Cureaa - a Clinical Trial of Upfront Haploidentical or Unrelated Donor BMT to Restore Normal Hematopoiesis in Aplastic Anemia, Blood and Marrow Transplant Clinical Trials Network (BMT CTN) #2207
Blood2024-11-05
Haploidentical bone marrow transplantation in patients with relapsed or refractory severe aplastic anaemia in the USA (BMT CTN 1502): a multicentre, single-arm, phase 2 trial.
2022-07-2754 citations
A phase II multicenter rabbit anti-thymocyte globulin trial in patients with myelodysplastic syndromes identifying a novel model for response prediction
Haematologica2014-01-3141 citations