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antidepressant therapy

DRUG5 trials

Sponsors

RAND, Otsuka Pharmaceutical Development & Commercialization, Inc., Jung-Sun Lee, Riphah International University

Conditions

DepressionDepression - Major Depressive DisorderDepressive DisorderDepressive SymptomsMajor Depressive DisorderMajor Depressive Disorder (MDD)Overweight or Obesity

Phase 3

A Trial to Evaluate the Efficacy, Safety & Tolerability of Brexpiprazole in the Maintenance Treatment of Adults With Major Depressive Disorder
CompletedNCT03538691
Otsuka Pharmaceutical Development & Commercialization, Inc.Major Depressive Disorder
Start: 2018-07-13End: 2022-07-29Updated: 2023-10-12

Phase 4

Comparative Trial of Antidepressant Treatment Models in HIV Care in Uganda
CompletedNCT02056106
RANDDepression
Start: 2013-01-31End: 2014-12-31Updated: 2015-10-05
Integrating a Stepped Care Model of Screening and Treatment for Depression Into Malawi's National HIV Care Delivery Platform
CompletedNCT04777006
RANDDepressive Disorder
Start: 2021-09-01End: 2025-06-30Updated: 2026-06-09

Unknown Phase

Efficacy and Safety of a Theta Burst Stimulation Protocol of Repetitive Transcranial Magnetic Stimulation in Treatment-Resistant Depression
Not yet recruitingNCT07529574
Jung-Sun LeeDepression - Major Depressive Disorder, Major Depressive Disorder (MDD)
Start: 2026-05-01End: 2027-12-31Target: 120Updated: 2026-04-14
Metformin as Adjunct Therapy in Depression-obesity Comorbidity: Clinical and Genetic Evaluation
RecruitingNCT07654179
Riphah International UniversityDepression, Depressive Disorder, Depressive Symptoms +1
Start: 2026-06-17End: 2027-06-11Target: 200Updated: 2026-08-07

Related Papers

Provider perceptions and experiences integrating depression treatment into chronic healthcare services in Neno District, Malawi: a qualitative study
BMC Health Services Research2025-12-10
Cost analysis of integrating depression treatment into chronic care in Malawi: evidence from a cluster randomised controlled trial.
2025-10-071 citations
Patient perspectives on group problem management plus for adults with major depressive disorder in rural Malawi
Global Health Action2025-05-091 citations
Effectiveness, cost-effectiveness, and positive externalities of integrated chronic care for adults with major depressive disorder in Malawi (IC3D): a stepped-wedge, cluster-randomised, controlled trial.
2024-10-307 citations
A double-blind, placebo-controlled, randomised withdrawal study of adjunctive brexpiprazole maintenance treatment for major depressive disorder
Acta Neuropsychiatrica2024-10-17
Depressive disorder at the household level: prevalence and correlates of depressive symptoms among household members
Global Health Action2023-08-095 citations
Prevalence and correlates of internalized stigma among adults with HIV and major depressive disorder in rural Malawi
AIDS Care2023-03-313 citations
Stepped care for depression at integrated chronic care centers (IC3) in Malawi: study protocol for a stepped-wedge cluster randomized controlled trial.
2021-09-165 citations
A Structured Protocol Model of Depression Care versus Clinical Acumen: A Cluster Randomized Trial of the Effects on Depression Screening, Diagnostic Evaluation, and Treatment Uptake in Ugandan HIV Clinics
PLoS ONE2016-05-1140 citations
INtegration of DEPression Treatment into HIV Care in Uganda (INDEPTH-Uganda): study protocol for a randomized controlled trial.
2014-06-2537 citations