Anti-mesothelin CAR-T cells
Sponsors
Chinese PLA General Hospital, Shanghai Pudong Hospital, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Zhejiang University
Conditions
Mesothelin-positive Advanced Malignant Solid TumorsMesothelin-positive Advanced Refractory Solid TumorsSolid Tumor, Adult
Phase 1
Study of CRISPR-Cas9 Mediated PD-1 and TCR Gene-knocked Out Mesothelin-directed CAR-T Cells in Patients With Mesothelin Positive Multiple Solid Tumors.
NCT03545815
Start: 2018-03-19End: 2020-12-30Target: 10Updated: 2020-08-10
Exploratory Study of Novel MSLN CAR-T Cell Therapy in Patients With MSLN-positive Advanced Refractory Solid Tumors
WithdrawnNCT05531708
Start: 2021-04-02End: 2026-04-30Updated: 2023-03-01
MSLN-targeted CAR-T Cells in Solid Tumors.
Not yet recruitingNCT05783089
Start: 2023-04-30End: 2027-04-30Target: 87Updated: 2023-03-24