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Anti-CD19-CAR CMV-specific T-lymphocytes

BIOLOGICAL3 trials

Sponsors

City of Hope Medical Center

Conditions

Acute Lymphoblastic LeukemiaB-Cell Non-Hodgkin LymphomaDiffuse Large B-Cell LymphomaHigh Grade B-Cell Non-Hodgkin's LymphomaIntermediate Grade B-Cell Non-Hodgkin's LymphomaMantle Cell LymphomaRecurrent B-Cell Non-Hodgkin LymphomaRecurrent Diffuse Large B-Cell Lymphoma

Early Phase 1

Allogeneic CMV-Specific CD19-CAR T Cells Plus CMV-MVA Triplex Vaccine After Matched Related Donor Hematopoietic Cell Transplant for the Treatment of Patients With High-Risk Acute Lymphoblastic Leukemia
RecruitingNCT06735690
City of Hope Medical CenterAcute Lymphoblastic Leukemia
Start: 2025-06-09End: 2029-03-07Target: 15Updated: 2025-11-12

Phase 1

Genetically Modified T-cells (CMV-Specific CD19-CAR T-cells) Plus a Vaccine (CMV-MVA Triplex) Following Stem Cell Transplantation for the Treatment of Intermediate or High Grade B-cell Non-Hodgkin Lymphoma
RecruitingNCT05432635
City of Hope Medical CenterB-Cell Non-Hodgkin Lymphoma, Diffuse Large B-Cell Lymphoma, Mantle Cell Lymphoma +5
Start: 2023-08-01End: 2028-12-30Target: 15Updated: 2026-02-23
Genetically Modified T-cells (CMV-Specific CD19-CAR T-cells) Plus a Vaccine (CMV-MVA Triplex) for the Treatment of Intermediate or High Grade B-Cell Non-Hodgkin Lymphoma
RecruitingNCT05801913
City of Hope Medical CenterHigh Grade B-Cell Non-Hodgkin's Lymphoma, Intermediate Grade B-Cell Non-Hodgkin's Lymphoma, Recurrent B-Cell Non-Hodgkin Lymphoma +1
Start: 2023-09-29End: 2028-12-30Target: 15Updated: 2026-03-05