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Angiotensin-(1-7)

DRUG10 trials

Sponsors

Vanderbilt University Medical Center, Vanderbilt University, University of Arizona, Amy Arnold, Stanford University

Conditions

AgingAutonomic Nervous System DisordersChronic Heart FailureCognitive ImpairmentCoronary Artery Bypass SurgeryCovid19HypertensionInfection, Coronavirus

Early Phase 1

Blood Pressure Lowering Effects of Angiotensin-(1-7) in Primary Autonomic Failure
TerminatedNCT02591173
Vanderbilt University Medical CenterAutonomic Nervous System Disorders, Orthostatic Hypotension, Dysautonomic, Pure Autonomic Failure +1
Start: 2016-02-29End: 2020-07-31Updated: 2021-01-12
Angiotensin 1-7 in Obesity Hypertension
TerminatedNCT03604289
Amy ArnoldHypertension, Obesity
Start: 2019-04-01End: 2023-06-03Updated: 2024-06-10
Angiotensin-(1-7) and Energy Expenditure in Human Obesity
Active, not recruitingNCT03777215
Amy ArnoldObesity
Start: 2019-09-26End: 2026-12-31Target: 30Updated: 2025-09-19
Angiotensin-(1-7) Cardiovascular Effects in Aging
RecruitingNCT05301192
Milton S. Hershey Medical CenterAging
Start: 2022-12-09End: 2026-12-31Target: 26Updated: 2025-09-19
Cardiovascular Effects of Angiotensin-(1-7) in Obesity Hypertension
RecruitingNCT06482853
Milton S. Hershey Medical CenterHypertension, Obesity
Start: 2025-01-23End: 2029-03-31Target: 52Updated: 2025-09-19

Phase 1

Metabolic Effects of Angiotensin-(1-7)
RecruitingNCT02646475
Vanderbilt UniversityHypertension, Insulin Resistance, Metabolic Cardiovascular Syndrome +1
Start: 2016-02-01End: 2029-12-01Target: 26Updated: 2026-05-22
Angiotensin (1-7) for the Treatment of COVID-19 in Hospitalized Patients
WithdrawnNCT04570501
Stanford UniversityCovid19
Start: 2022-02-28End: 2022-08-31Updated: 2022-03-03
Use of Angiotensin-(1-7) in COVID-19
CompletedNCT04633772
Erasme University HospitalInfection, Coronavirus, Respiratory Failure
Start: 2020-08-05End: 2021-11-01Updated: 2021-11-09

Phase 2

Angiotensin (1-7) Treatment to Improve Cognitive Functioning in Heart Failure Patients
SuspendedNCT03159988
University of ArizonaChronic Heart Failure, Cognitive Impairment
Start: 2016-04-30End: 2026-06-01Updated: 2025-06-04
Evaluation of the Safety and Efficacy of Ang-(1-7) to Enhance Cognitive Function in Participants Undergoing CABG
TerminatedNCT03252093
University of ArizonaCognitive Impairment, Coronary Artery Bypass Surgery
Start: 2017-07-20End: 2022-11-15Updated: 2025-06-04

Related Papers

Angiotensin-(1-7) infusion in COVID-19 patients admitted to the ICU: a seamless phase 1-2 randomized clinical trial.
2024-09-046 citations