Aminolevulinic Acid

DRUG20 trials

Sponsors

Kinouchi Kenichiro, Miyake Makito, Roswell Park Cancer Institute, The Cleveland Clinic, Advocate Hospital System

Conditions

Actinic KeratosesActinic KeratosisAdult Anaplastic AstrocytomaAdult Anaplastic OligodendrogliomaAdult Giant Cell GlioblastomaAdult GlioblastomaAdult GliosarcomaAdult Mixed Glioma

Early Phase 1

Topical Aminolevulinic Acid in Patients With Nonmelanoma Skin Cancer

TerminatedNCT00663910

The Cleveland ClinicNon-melanomatous Skin Cancer

Start: 2008-03-31End: 2009-10-31Updated: 2017-01-02

Phase 1

Study of Aminolevulinic Acid to Enhance Visualization and Resection of Malignant Glial Tumors of the Brain

CompletedNCT00671710

Advocate Hospital SystemBrain Tumors

Start: 2008-04-30End: 2010-11-30Target: 26Updated: 2011-01-14

Aminolevulinic Acid During Surgery in Treating Patients With Malignant Brain Tumors

TerminatedNCT01148966

University of WashingtonAdult Anaplastic Astrocytoma, Adult Anaplastic Oligodendroglioma, Adult Giant Cell Glioblastoma +4

Start: 2010-06-30Updated: 2017-02-15

Fluorescent Aided Resection and Evaluation of Soft Tissue Sarcomas (FLARES)

WithdrawnNCT06252727

University of California, DavisSoft Tissue Sarcoma, Soft Tissue Sarcoma Adult

Start: 2024-07-31End: 2026-05-31Updated: 2024-08-15

Fluorescence Image Guided Surgery Followed by Intraoperative Photodynamic Therapy for Improving Local Tumor Control in Patients With Locally Advanced or Recurrent Colorectal Cancer

RecruitingNCT06307548

Roswell Park Cancer InstituteLocally Advanced Colorectal Carcinoma, Recurrent Colorectal Carcinoma, Stage III Colorectal Cancer

Start: 2024-07-30End: 2027-06-01Target: 21Updated: 2026-06-05

Phase 2

Photodynamic Therapy in Treating Patients With Skin Cancer

CompletedNCT00002975

Roswell Park Cancer InstituteNon-melanomatous Skin Cancer, Precancerous Condition

Start: 1997-02-28End: 2010-04-30Updated: 2013-10-10

Imaging Procedure Using ALA in Finding Residual Tumor in Grade IV Malignant Astrocytoma

CompletedNCT00752323

Andrew Sloan, MDBrain and Central Nervous System Tumors

Start: 2009-12-08End: 2018-10-14Updated: 2021-09-17

ALA-PDT Versus Vehicle PDT for Treatment of AK and Reduction of New NMSC in Solid Organ Transplant Recipients

TerminatedNCT00865878

DUSA Pharmaceuticals, Inc.Actinic Keratoses, Skin Neoplasms

Start: 2009-05-31End: 2011-09-30Updated: 2011-10-21

Safety Study of Aminolevulinic Acid (ALA) to Improve Visibility of Brain Tumors During Surgery

CompletedNCT00961090

Matthew R QuigleyGlioblastoma

Start: 2009-09-30End: 2015-04-23Updated: 2019-04-12

A Study of Aminolevulinic Acid Used to Enhance Visualization and Surgical Removal of Brain Tumors

TerminatedNCT01351519

MultiCare Health System Research InstituteAstrocytoma, Glioblastoma, Glioblastoma Multiforme +2

Start: 2011-05-31End: 2015-01-31Updated: 2016-03-17

Aminolevulinic Acid in Visualizing a Tumor During Surgery in Patients With Glioblastoma Multiforme

TerminatedNCT01575275

Michael Vogelbaum, MD, PhDAdult Giant Cell Glioblastoma, Adult Glioblastoma, Adult Gliosarcoma +1

Start: 2012-05-31End: 2014-08-31Updated: 2018-07-31

Controlled Study of the Occurrence of Actinic Keratosis on the Face After Cryotherapy + Aminolevulinic Acid (ALA) Photodynamic Therapy

CompletedNCT02239679

DUSA Pharmaceuticals, Inc.Actinic Keratosis

Start: 2014-09-30End: 2016-09-30Updated: 2018-08-24

Photodynamic Therapy for Benign Dermal Neurofibromas- Phase II

TerminatedNCT02728388

Donald BaselNEUROFIBROMATOSIS 1

Start: 2016-09-16End: 2026-03-28Target: 30Updated: 2026-07-10

A prospective study of oral 5-AMinolevulinic acid for preventing adverse events in patients with localized prostate cancer undergoing low-dose rate BrachythERapy

Active, not recruitingJPRN-jRCTs051190077

Miyake MakitoLocalized prostate cancer prostate, neoplasm

Start: 2019-12-05Target: 50Updated: 2026-06-29

Phase 4

Daylight PDT for Actinic Keratoses: a Multicentre Study Comparing Two Photosensitizers (BF-200 ALA Versus MAL)

CompletedNCT02464709

Joint Authority for Päijät-Häme Social and Health CareActinic Keratosis, Natural Daylight Photodynamic Therapy

Start: 2015-06-30End: 2017-10-31Updated: 2019-08-28

Study of Daylight Photodynamic Therapy With Aminolevulinic Acid for Actinic Keratoses

CompletedNCT03327831

University of California, IrvineActinic Keratosis

Start: 2015-04-30End: 2017-07-31Updated: 2024-06-27

Unknown Phase

Photodynamic Therapy Using Topical Aminolevulinic Acid in Treating Patients With Actinic Keratosis

TerminatedNCT00524485

Roswell Park Cancer InstitutePrecancerous/Nonmalignant Condition

Start: 2005-05-31End: 2009-05-31Updated: 2017-06-14

The Use of Microneedles in Photodynamic Therapy

CompletedNCT01812837

University of California, DavisActinic Keratosis

Start: 2012-07-31End: 2014-03-31Updated: 2017-06-15

The Use of Microneedles to Expedite Treatment Time in Photodynamic Therapy

CompletedNCT02594644

University of California, DavisKeratosis, Actinic

Start: 2014-11-06End: 2016-06-22Updated: 2018-11-29

Active, not recruitingJPRN-jRCTs031190094

Kinouchi Kenichironone

Start: 2020-02-20Target: 54Updated: 2026-06-29

Related Papers

Oral 5-aminolevulinic Acid for Patients With Localized Prostate Cancer Undergoing Low-dose-rate Brachytherapy: AMBER Trial.

2024-11-012 citations

A prospective, single-arm trial of fluorescent ureteroscopy-assisted thulium-holmium:YAG dual laser ablation for upper urinary tract cancer: Study protocol of the FLUAM trial.

2022-03-025 citations

Photodynamic Therapy for Benign Cutaneous Neurofibromas Using Aminolevulinic Acid Topical Application and 633 nm Red Light Illumination

Photobiomodulation Photomedicine and Laser Surgery2021-01-2017 citations

A prospective study of oral 5-aminolevulinic acid to prevent adverse events in patients with localized prostate cancer undergoing low-dose-rate brachytherapy: Protocol of the AMBER study.

2020-06-173 citations

A Randomized Trial of Broad Area ALA–PDT for Field Cancerization Mitigation in High-Risk Patients

Journal of Drugs in Dermatology2020-04-016 citations

Effect of Expedited Microneedle-Assisted Photodynamic Therapy for Field Treatment of Actinic Keratoses

JAMA Dermatology2017-05-1758 citations