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AMG 510

DRUG14 trials

Sponsors

Amgen, M.D. Anderson Cancer Center, Criterium, Inc.

Conditions

Advanced/Metastatic Solid Tumors With KRAS p.G12C MutationHealthy ParticipantsHealthy SubjectsHealthy VolunteersKRAS p, G12c Mutated /Advanced Metastatic NSCLCLocally Advanced Metastatic NSCLCLocally Advanced Unresectable NSCLCLung Cancer

Phase 1

AMG 510 Ethnic Sensitivity Study (CodeBreaK 105).
CompletedNCT04380753
AmgenAdvanced/Metastatic Solid Tumors With KRAS p.G12C Mutation
Start: 2020-04-28End: 2026-02-09Updated: 2026-05-06
A Phase I/II Study of AMG 510 in Combination With MVASI in Patients With Advanced, Unresectable or Metastatic KRAS G12C Mutant NSCLC With Asymptomatic Brain Metastasis
WithdrawnNCT05180422
Criterium, Inc.Non Small Cell Lung Cancer
Start: 2022-06-15End: 2023-01-31Updated: 2023-10-18
Study to Evaluate the Drug-drug Interactions Between Metformin and AMG 510 in Healthy Participants
CompletedNCT05550129
AmgenHealthy Volunteers
Start: 2019-11-13End: 2019-11-25Updated: 2025-03-05
A Study to Evaluate the Drug-drug Interaction Effect of Itraconazole on the Pharmacokinetics (PK) of AMG 510 in Healthy Participants
CompletedNCT05568082
AmgenHealthy Participants
Start: 2019-12-03End: 2019-12-17Updated: 2025-03-05
A Study to Evaluate the Relative Bioavailability of AMG 510 Administered as Tablets and as a Water Dispersion in Healthy Participants
CompletedNCT05571163
AmgenHealthy Participants
Start: 2020-03-06End: 2020-06-14Updated: 2022-10-07
A Study to Evaluate the Drug-drug Interaction Effect of Rifampin on the Pharmacokinetics of AMG 510 in Healthy Participants
CompletedNCT05577624
AmgenHealthy Participants
Start: 2019-11-05End: 2019-12-01Updated: 2025-03-18
A Study of the Absorption, Metabolism, and Excretion of [14C]-AMG 510 Following a Single Oral Dose in Healthy Male Subjects
CompletedNCT05578859
AmgenHealthy Subjects
Start: 2020-03-11End: 2020-03-24Updated: 2022-11-07
Study to Evaluate the Drug-drug Interaction Effect of Omeprazole on the Pharmacokinetics (PK) of AMG 510 in Healthy Participants
CompletedNCT05581992
AmgenHealthy Participants
Start: 2020-01-06End: 2020-01-26Updated: 2025-03-18
A Study to Assess the Effect of Food on the Pharmacokinetics (PK) of AMG 510 in Healthy Participants
CompletedNCT05581758
AmgenHealthy Participants
Start: 2019-11-14End: 2019-12-09Updated: 2025-03-05
Study to Evaluate the Effect of AMG 510 on the Pharmacokinetics (PK) of Digoxin in Healthy Participants
CompletedNCT05598281
AmgenHealthy Participants
Start: 2019-11-05End: 2019-11-19Updated: 2025-04-02
A Study to Evaluate the Impact of Acid-reducing Agents on the Pharmacokinetics (PK) of AMG 510 in Healthy Participants
CompletedNCT05599828
AmgenHealthy Participants
Start: 2020-07-17End: 2020-09-13Updated: 2024-12-12

Phase 2

Phase 3

Unknown Phase

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