AMG 510
Sponsors
Amgen, M.D. Anderson Cancer Center, Criterium, Inc.
Conditions
Advanced/Metastatic Solid Tumors With KRAS p.G12C MutationHealthy ParticipantsHealthy SubjectsHealthy VolunteersKRAS p, G12c Mutated /Advanced Metastatic NSCLCLocally Advanced Metastatic NSCLCLocally Advanced Unresectable NSCLCLung Cancer
Phase 1
AMG 510 Ethnic Sensitivity Study (CodeBreaK 105).
CompletedNCT04380753
Start: 2020-04-28End: 2026-02-09Updated: 2026-05-06
A Phase I/II Study of AMG 510 in Combination With MVASI in Patients With Advanced, Unresectable or Metastatic KRAS G12C Mutant NSCLC With Asymptomatic Brain Metastasis
WithdrawnNCT05180422
Start: 2022-06-15End: 2023-01-31Updated: 2023-10-18
Study to Evaluate the Drug-drug Interactions Between Metformin and AMG 510 in Healthy Participants
CompletedNCT05550129
Start: 2019-11-13End: 2019-11-25Updated: 2025-03-05
A Study to Evaluate the Drug-drug Interaction Effect of Itraconazole on the Pharmacokinetics (PK) of AMG 510 in Healthy Participants
CompletedNCT05568082
Start: 2019-12-03End: 2019-12-17Updated: 2025-03-05
A Study to Evaluate the Relative Bioavailability of AMG 510 Administered as Tablets and as a Water Dispersion in Healthy Participants
CompletedNCT05571163
Start: 2020-03-06End: 2020-06-14Updated: 2022-10-07
A Study to Evaluate the Drug-drug Interaction Effect of Rifampin on the Pharmacokinetics of AMG 510 in Healthy Participants
CompletedNCT05577624
Start: 2019-11-05End: 2019-12-01Updated: 2025-03-18
A Study of the Absorption, Metabolism, and Excretion of [14C]-AMG 510 Following a Single Oral Dose in Healthy Male Subjects
CompletedNCT05578859
Start: 2020-03-11End: 2020-03-24Updated: 2022-11-07
Study to Evaluate the Drug-drug Interaction Effect of Omeprazole on the Pharmacokinetics (PK) of AMG 510 in Healthy Participants
CompletedNCT05581992
Start: 2020-01-06End: 2020-01-26Updated: 2025-03-18
A Study to Assess the Effect of Food on the Pharmacokinetics (PK) of AMG 510 in Healthy Participants
CompletedNCT05581758
Start: 2019-11-14End: 2019-12-09Updated: 2025-03-05
Study to Evaluate the Effect of AMG 510 on the Pharmacokinetics (PK) of Digoxin in Healthy Participants
CompletedNCT05598281
Start: 2019-11-05End: 2019-11-19Updated: 2025-04-02
A Study to Evaluate the Impact of Acid-reducing Agents on the Pharmacokinetics (PK) of AMG 510 in Healthy Participants
CompletedNCT05599828
Start: 2020-07-17End: 2020-09-13Updated: 2024-12-12