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AMG 176

DRUG3 trials

Sponsors

Amgen, AbbVie

Conditions

Acute Myeloid LeukemiaChronic Myelomonocytic LeukemiaDiffuse Large B-cell LymphomaHigher Risk Myelodysplastic SyndromeNon-Hodgkin's LymphomaRelapsed or Refractory Acute Myeloid LeukemiaRelapsed or Refractory Multiple Myeloma

Phase 1

AMG 176 First in Human Trial in Participants With Relapsed or Refractory Multiple Myeloma and Participants With Relapsed or Refractory Acute Myeloid Leukemia
TerminatedNCT02675452
AmgenRelapsed or Refractory Acute Myeloid Leukemia, Relapsed or Refractory Multiple Myeloma
Start: 2016-06-13End: 2024-05-27Updated: 2025-07-09
A Study of Venetoclax and AMG 176 in Patients With Relapsed/Refractory Hematologic Malignancies
TerminatedNCT03797261
AbbVieAcute Myeloid Leukemia, Diffuse Large B-cell Lymphoma, Non-Hodgkin's Lymphoma
Start: 2019-03-18End: 2019-12-30Updated: 2021-12-07
AMG 176 With Azacitidine in Subjects With Myelodysplastic Syndrome /Chronic Myelomonocytic Leukemia
TerminatedNCT05209152
AmgenChronic Myelomonocytic Leukemia, Higher Risk Myelodysplastic Syndrome
Start: 2022-11-14End: 2023-12-19Updated: 2025-07-14

Related Papers

Saga of MCL1 inhibitors in multiple myeloma.
2025-11-07
A phase I study of the myeloid cell leukemia 1 (MCL1) inhibitor tapotoclax (AMG 176) in patients with myelodysplastic syndromes after hypomethylating agent failure.
Journal of Clinical Oncology2024-06-011 citations
Selective MCL-1 inhibitor ABBV-467 is efficacious in tumor models but is associated with cardiac troponin increases in patients
Communications Medicine2023-10-2552 citations
A Phase Ib Study of the Safety and Efficacy of Venetoclax When Combined with Escalating Doses of Omacetaxine in Patients with Relapsed/Refractory Acute Myeloid Leukemia Failing Treatment with Venetoclax-Containing Regimens (VEN-OM)
Blood2022-11-15
Unmasking BCL-2 Addiction in Synovial Sarcoma by Overcoming Low NOXA
Cancers2021-05-1214 citations
Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia.
2018-12-17358 citations