Alvocidib Hydrochloride

DRUG5 trials

Sponsors

National Cancer Institute (NCI), M.D. Anderson Cancer Center

Conditions

AnemiaChronic Lymphocytic LeukemiaExtranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid TissueNodal Marginal Zone LymphomaProlymphocytic LeukemiaRecurrent Acute Myeloid LeukemiaRecurrent Adult Diffuse Large Cell LymphomaRecurrent Adult Diffuse Mixed Cell Lymphoma

Phase 1

Bortezomib and Flavopiridol in Treating Patients With Recurrent or Refractory Indolent B-Cell Neoplasms

CompletedNCT00082784

National Cancer Institute (NCI)Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue, Nodal Marginal Zone Lymphoma, Recurrent Adult Diffuse Large Cell Lymphoma +10

Start: 2004-03-31End: 2014-09-30Updated: 2014-12-23

Lenalidomide and Alvocidib in Treating Patients With Relapsed or Refractory B-cell Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

CompletedNCT00735930

National Cancer Institute (NCI)Anemia, Chronic Lymphocytic Leukemia, Prolymphocytic Leukemia +3

Start: 2008-08-31End: 2014-11-30Updated: 2015-04-02

Cyclophosphamide, Alvocidib, and Rituximab in Treating Patients With High Risk B-Cell Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

TerminatedNCT01076556

National Cancer Institute (NCI)Chronic Lymphocytic Leukemia, Prolymphocytic Leukemia, Recurrent Small Lymphocytic Lymphoma +9

Start: 2010-04-30Updated: 2015-11-11

Alvocidib in Combination With Decitabine and Venetoclax in Patients With Relapsed or Refractory AML or as Frontline Therapy in Unfit Patients With AML

WithdrawnNCT04493099

M.D. Anderson Cancer CenterRecurrent Acute Myeloid Leukemia, Refractory Acute Myeloid Leukemia

Start: 2020-10-31End: 2020-10-12Updated: 2020-11-12

Phase 2

Alvocidib and Oxaliplatin With or Without Fluorouracil and Leucovorin Calcium in Treating Patients With Relapsed or Refractory Germ Cell Tumors

CompletedNCT00957905

National Cancer Institute (NCI)Recurrent Extragonadal Seminoma, Recurrent Malignant Extragonadal Germ Cell Tumor, Recurrent Malignant Extragonadal Non-Seminomatous Germ Cell Tumor +6

Start: 2009-06-30End: 2014-08-31Updated: 2017-03-10

Related Papers

Multicenter sequential phase II study of flavopiridol plus oxaliplatin (Alvocidib) with or without 5-FU and leucovorin (LV) for patients (pts) with refractory germ cell tumors (GCT) including late relapse (LR).

Journal of Clinical Oncology2014-02-014 citations