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ALVAC-HIV

BIOLOGICAL4 trials

Sponsors

U.S. Army Medical Research and Development Command, HIV Vaccine Trials Network, National Institute of Allergy and Infectious Diseases (NIAID)

Conditions

HIV InfectionHIV Infections

Phase 1

Safety of and Immune Response to Vaccination With 2 Experimental HIV Vaccines in Healthy Adults
CompletedNCT02109354
HIV Vaccine Trials NetworkHIV Infection
Start: 2013-06-18End: 2015-02-02Updated: 2019-06-21
A Safety and Immune Response Study of 2 Experimental HIV Vaccines
CompletedNCT02404311
National Institute of Allergy and Infectious Diseases (NIAID)HIV Infection
Start: 2015-02-02End: 2018-08-07Updated: 2021-11-05

Phase 2

Study of Late Boost Strategies for HIV-uninfected Participants From Protocol RV 144
NCT01435135
U.S. Army Medical Research and Development CommandHIV Infections
Start: 2012-04-30End: 2021-07-31Target: 162Updated: 2020-11-03
Study of Boosting Strategies After Vaccination With ALVAC-HIV and AIDSVAX® B/E
NCT01931358
U.S. Army Medical Research and Development CommandHIV Infections
Start: 2013-09-24End: 2021-12-31Target: 360Updated: 2021-03-26

Related Papers

ALVAC-prime and monomeric gp120 protein boost induces distinct HIV-1 specific humoral and cellular responses compared with adenovirus-prime and trimeric gp140 protein boost
PLOS Global Public Health2025-04-11
A polyvalent DNA prime with matched polyvalent protein/GLA-SE boost regimen elicited the most robust and broad IgG and IgG3 V1V2 binding antibody and CD4+ T cell responses among 13 HIV vaccine trials
Emerging Microbes & Infections2025-04-071 citations
Safety and immunogenicity after a 30-month boost of a subtype C ALVAC-HIV (vCP2438) vaccine prime plus bivalent subtype C gp120/MF59 vaccine boost (HVTN 100): A phase 1–2 randomized double-blind placebo-controlled trial
PLOS Global Public Health2024-09-20
The Question of HIV Vaccine: Why Is a Solution Not Yet Available?
Journal of Immunology Research2024-01-0112 citations
Additional boosting to the RV144 vaccine regimen increased Fc-mediated effector function magnitude but not durability
AIDS2023-06-0113 citations
Viral vector delivered immunogen focuses HIV-1 antibody specificity and increases durability of the circulating antibody recall response
PLoS Pathogens2023-05-317 citations
Participants' characteristics and motivations to screen for HIV vaccine and monoclonal antibody trials in KwaZulu-Natal, South Africa.
2021-12-113 citations
Safety and immune responses after a 12-month booster in healthy HIV-uninfected adults in HVTN 100 in South Africa: A randomized double-blind placebo-controlled trial of ALVAC-HIV (vCP2438) and bivalent subtype C gp120/MF59 vaccines
PLoS Medicine2020-02-2448 citations
Late boosting of the RV144 regimen with AIDSVAX B/E and ALVAC-HIV in HIV-uninfected Thai volunteers: a double-blind, randomised controlled trial.
2020-02-0638 citations
Landscapes of binding antibody and T-cell responses to pox-protein HIV vaccines in Thais and South Africans.
2020-01-3016 citations
Safety and immunogenicity of a multivalent HIV vaccine comprising envelope protein with either DNA or NYVAC vectors (HVTN 096): a phase 1b, double-blind, placebo-controlled trial.
2019-10-0738 citations
Subtype C ALVAC-HIV and bivalent subtype C gp120/MF59 HIV-1 vaccine in low-risk, HIV-uninfected, South African adults: a phase 1/2 trial.
2018-06-1888 citations
Characterization of HIV-1 gp120 antibody specificities induced in anogenital secretions of RV144 vaccine recipients after late boost immunizations
PLoS ONE2018-04-2717 citations
Boosting of HIV envelope CD4 binding site antibodies with long variable heavy third complementarity determining region in the randomized double blind RV305 HIV-1 vaccine trial
PLoS Pathogens2017-02-2448 citations
Randomized, Double-Blind Evaluation of Late Boost Strategies for HIV-Uninfected Vaccine Recipients in the RV144 HIV Vaccine Efficacy Trial
The Journal of Infectious Diseases2017-02-1770 citations
Uptake of Genital Mucosal Sampling in HVTN 097, a Phase 1b HIV Vaccine Trial in South Africa
PLoS ONE2014-11-179 citations