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Alunbrig 30 mg film-coated tablets

DRUG5 trials

Sponsors

Intergroupe Francophone De Cancerologie Thoracique, Fundacion GECP, Prinses Maxima Centrum voor Kinderoncologie B.V., Frankfurter Institut Fuer Klinische Krebsforschung IKF GmbH, Universita' Degli Studi Di Torino

Conditions

ALK+ NSCLCALK+ non-small cell lung cancerAnaplastic Large Cell Lymphoma (ALCL)Inflammatory Myofibroblastic Tumors (IMT)Non Small Cell Lung CancerOther solid tumorsadvanced ALK-positive non-small cell lung cancerlocally advanced (stage III) and not suitable for curative treatment

Phase 1

Phase 2

IFCT-2101 MASTERPROTOCOL ALK A phase II randomized, open-labelled, multicenter study of safety and efficacy of brigatinib and carboplatin-pemetrexed combination therapy or brigatinib monotherapy as first-line treatment in patients with advanced ALK-positive non-small cell lung cancer
Active, not recruitingCTIS2023-510387-13-00
Intergroupe Francophone De Cancerologie Thoraciqueadvanced ALK-positive non-small cell lung cancer
Start: 2022-05-18Target: 110Updated: 2025-02-11
Clinical Utility of Liquid Biopsy as a tool to assess the evolution of brigatinib treated patients with non-small cell lung cancer with EML4-ALK translocation: an exploratory study (CUBIK)
Active, not recruitingCTIS2024-511317-38-00
Fundacion GECPALK+ non-small cell lung cancer
Start: 2020-05-04Target: 33Updated: 2025-12-18
ABP - Advancing Brigatinib Properties in anaplastic lymphoma kinase positive non-small cell lung cancer (ALK+ NSCLC) patients by deep phenotyping
Active, not recruitingCTIS2024-513947-94-00
Frankfurter Institut Fuer Klinische Krebsforschung IKF GmbHALK+ NSCLC, locally advanced (stage III) and not suitable for curative treatment, or metastatic (stage IV) ALK+ NSCLC
Start: 2020-03-30Target: 118Updated: 2025-12-17
DYNAMIC ” IDentifY the best therapeutic sequeNcing strAtegy in oncogene addICted NSCLC:” “A multi-arms prospective, randomized phase II study to evaluate the best sequential therapeutic strategis in patients with metastatic non-small cell lung cancer harboring targetable genomic driver alterations”
Not yet recruitingCTIS2026-525268-16-00
Universita' Degli Studi Di TorinoNon Small Cell Lung Cancer
Target: 962Updated: 2026-10-19