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Alpha 1-Antitrypsin

DRUG6 trials

Sponsors

Virginia Commonwealth University, Soroka University Medical Center, Massachusetts General Hospital, University of Minnesota, John Levine

Conditions

Acute Myocardial InfarctionAlpha 1-Antitrypsin DeficiencyGVHDGraft-versus-host-diseaseKidney TransplantPancreatitis, Chronic; Diabetes; TransplantPost Cardiac Surgery Systemic Inflammatory ResponseType 1 Diabetes

Phase 1

Alpha-1 Anti-Trypsin (AAT) Treatment in Acute Myocardial Infarction
CompletedNCT01936896
Virginia Commonwealth UniversityAcute Myocardial Infarction
Start: 2013-12-31End: 2014-07-31Updated: 2016-02-12
Single Dose Administration of Alpha-1 Anti-Trypsin for the Amelioration of Organ Injury in Patients Undergoing Cardiac Surgery
NCT02191839
Soroka University Medical CenterPost Cardiac Surgery Systemic Inflammatory Response
Start: 2014-07-31End: 2015-07-31Target: 20Updated: 2014-07-16

Phase 2

Multicenter Trial of the Effect of AAT on Islet Transplant Engraftment and Durability After Renal Transplant
CompletedNCT02464878
Massachusetts General HospitalKidney Transplant, Type 1 Diabetes
Start: 2017-01-31End: 2022-12-31Updated: 2023-12-22
A Proof of Concept Pilot Trial of Alpha-1-Antitrypsin for Pre-Emption Of Steroid-Refractory Acute GVHD
CompletedNCT03459040
John LevineGraft-versus-host-disease, GVHD
Start: 2018-08-17End: 2020-08-21Updated: 2021-07-12

Phase 3

Phase III, Efficacy and Safety of Kamada-AAT for Inhalation
RecruitingNCT04204252
Kamada, Ltd.Alpha 1-Antitrypsin Deficiency
Start: 2019-11-25End: 2031-06-30Target: 220Updated: 2025-09-04

Phase 4

Anti-inflammatory Therapy to Improve Outcomes After TPIAT
CompletedNCT02713997
University of MinnesotaPancreatitis, Chronic; Diabetes; Transplant
Start: 2016-12-31End: 2025-05-01Updated: 2025-06-24

Related Papers

Governmental Non-Pharmaceutical Interventions during the COVID-19 Pandemic and the COPD Exacerbation and Respiratory Infection Rate in Patients with Alpha-1 Antitrypsin Deficiency
COPD Journal of Chronic Obstructive Pulmonary Disease2023-09-04
Biomarker-guided preemption of steroid-refractory graft-versus-host disease with α-1-antitrypsin
Blood Advances2020-12-0935 citations
Inhibiting the Inflammatory Injury After Myocardial Ischemia Reperfusion With Plasma-Derived Alpha-1 Antitrypsin: A Post Hoc Analysis of the VCU-α1RT Study.
2018-06-0121 citations