Alogenic sclerocorneal limbus stem adult limbal cells expanded combined with alogenic corneal diferenciated adult keratocytes expanded in biological matrix

DRUG2 trials

Sponsors

Fundacion Publica Para La Investigacion Biosanitaria De Andalucia Oriental Alejandro Otero, Red Andaluza De Diseno Y Traslacion De Terapias Avanzadas Fundacion Publica Andaluza Progreso Y Salud

Conditions

Corneal trophic ulcers refractory to conventional treatment or sequelae of previous ulcers (such as stromal thinning or fibrosis)Corneal ulcerassociated or not with limbal insufficiency of the same eye.

Phase 1

Multicenter clinical trial to evaluate the safety and feasibility of allogeneic tissue engineered product (human nanostructured artificial cornea) in patients with advanced corneal trophic ulcers refractory to (ophtalmic) conventional treatment.

Active, not recruitingCTIS2024-515481-13-00

Red Andaluza De Diseno Y Traslacion De Terapias Avanzadas Fundacion Publica Andaluza Progreso Y SaludCorneal trophic ulcers refractory to conventional treatment or sequelae of previous ulcers (such as stromal thinning or fibrosis), associated or not with limbal insufficiency of the same eye.

Start: 2024-07-05Target: 20Updated: 2024-07-05

Phase 2

Phase IIb, randomised, controlled, unblinded, multicentre, clinical trial to evaluate the clinical efficacy of a nanostructured fibrin-agarose artificial cornea model (NANOULCOR) in patients with severe corneal ulcers.

RecruitingCTIS2023-506856-25-00

Fundacion Publica Para La Investigacion Biosanitaria De Andalucia Oriental Alejandro OteroCorneal ulcer

Start: 2025-03-12Target: 30Updated: 2025-09-16