Allopregnanolone

DRUG6 trials

Conditions

Alcohol Use DisorderAlzheimer DementiaFragile X-associated Tremor/Ataxia SyndromeLate Onset Alzheimer DiseaseNeurodegenerative DiseasesParkinson DiseaseTraumatic Brain Injury (TBI)

Phase 1

Allopregnanolone Regenerative Therapeutic for Early Alzheimer's Disease: Intramuscular Study

TerminatedNCT03748303

University of ArizonaAlzheimer Dementia

Start: 2019-10-01End: 2022-12-21Updated: 2026-03-13

Effect of Allopregnanolone on Stress-induced Craving

CompletedNCT04015869

Yale UniversityAlcohol Use Disorder

Start: 2019-07-01End: 2023-09-01Updated: 2025-08-22

Allopregnanolone as a Regenerative Treatment for Parkinson's Disease

CompletedNCT06263010

Roberta BrintonParkinson Disease

Start: 2024-01-12End: 2025-07-15Updated: 2026-03-13

Phase 2

Treatment of Fragile-X Associated Tremor/Ataxia Syndrome (FXTAS) With Allopregnanolone

CompletedNCT02603926

Randi J. Hagerman, MDFragile X-associated Tremor/Ataxia Syndrome

Start: 2015-10-31End: 2017-12-31Updated: 2018-12-06

Allopregnanolone in Chronic Complex Traumatic Brain Injury

Not yet recruitingNCT04003285

VA Office of Research and DevelopmentTraumatic Brain Injury (TBI)

Start: 2026-10-01End: 2027-06-01Target: 132Updated: 2026-09-08

Allopregnanolone Regenerative Therapeutic for Mild Alzheimer's Disease

Active, not recruitingNCT04838301

University of ArizonaAlzheimer Dementia, Late Onset Alzheimer Disease, Neurodegenerative Diseases

Start: 2023-08-15End: 2027-03-18Target: 100Updated: 2026-06-30

Alzheimer s & Dementia Translational Research & Clinical Interventions2022-01-0120 citations

Precision Functional Assessment for Alzheimer’s disease (PFA‐AD): A pilot study framework

Alzheimer s & Dementia2020-12-01

Pharmacokinetics and safety profile of intramuscular administration of allopregnanolone in patients with Alzheimer’s disease

Alzheimer s & Dementia2020-12-01

Allopregnanolone

Sponsors

Conditions

Phase 1

Phase 2

Related Papers