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Allogeneic CD34+-enriched and CD45RA-depleted PBSCs

BIOLOGICAL2 trials

Sponsors

Fred Hutchinson Cancer Center

Conditions

Acute Biphenotypic LeukemiaAcute LeukemiaAcute Leukemia of Ambiguous LineageAcute Lymphoblastic LeukemiaAcute Myeloid LeukemiaAcute Undifferentiated LeukemiaBlastic Plasmacytoid Dendritic Cell NeoplasmBurkitt Leukemia

Phase 2

Graft Versus Host Disease-Reduction Strategies for Donor Blood Stem Cell Transplant Patients With Acute Leukemia or Myelodysplastic Syndrome (MDS)
RecruitingNCT03970096
Fred Hutchinson Cancer CenterAcute Leukemia, Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia +2
Start: 2019-11-19End: 2029-12-31Target: 120Updated: 2026-03-12
Depletion of CD45RA Positive Naive T Cells for the Prevention of Graft Versus Host Disease in Older Patients Undergoing Allogeneic Hematopoietic Cell Transplantation for Acute Leukemia or Myelodysplastic Syndrome
Not yet recruitingNCT07819396
Fred Hutchinson Cancer CenterAcute Biphenotypic Leukemia, Acute Leukemia, Acute Leukemia of Ambiguous Lineage +11
Start: 2027-01-01End: 2031-06-01Target: 52Updated: 2026-09-14

Related Papers

Memory CD4+ T Cells Recognize Divergent HLA-DP Immunopeptidomes and Contribute to Leukemia Control after Allogeneic HCT
Blood2024-11-051 citations
Identification of Microbiota-Reactive CD4+ T Cells in the Post-Transplant Setting
Blood2024-11-05