Allogeneic Bone Marrow-Derived Human Mesenchymal Stem Cells

BIOLOGICAL2 trials

Sponsors

Michael A. Matthay, Ottawa Hospital Research Institute

Conditions

Acute Respiratory Distress SyndromeInfectionInflammationPathologic ProcessesSepsisSeptic ShockShockSystemic Inflammatory Response Syndrome

Phase 1

Human Mesenchymal Stem Cells For Acute Respiratory Distress Syndrome

CompletedNCT01775774

Michael A. MatthayAcute Respiratory Distress Syndrome

Start: 2013-07-31End: 2015-02-28Updated: 2017-08-14

Phase 2

Cellular Immunotherapy for Septic Shock

Ottawa Hospital Research InstituteInfection, Inflammation, Pathologic Processes +4

Start: 2018-03-31End: 2020-10-31Target: 114Updated: 2017-12-11

Related Papers

The Effect of Mesenchymal Stromal Cells on the Mortality of Patients with Sepsis and Septic Shock: A Promising Therapy

Emergency Medicine International2022-06-2423 citations

Safety and efficacy of human umbilical cord mesenchymal stem cells for the treatment of sepsis induced by pneumonia: study protocol for a single-centre, randomised single-blind parallel group trial

BMJ Open2022-04-013 citations

A phase Ib/IIa, randomised, double-blind, multicentre trial to assess the safety and efficacy of expanded Cx611 allogeneic adipose-derived stem cells (eASCs) for the treatment of patients with community-acquired bacterial pneumonia admitted to the intensive care unit.

2020-11-2511 citations

Allogeneic human umbilical cord-derived mesenchymal stem cells for severe bronchopulmonary dysplasia in children: study protocol for a randomized controlled trial (MSC-BPD trial)

Trials2020-01-3126 citations

Mesenchymal stem (stromal) cells for treatment of ARDS: a phase 1 clinical trial.

2014-12-17555 citations

Design and implementation of the START (STem cells for ARDS Treatment) trial, a phase 1/2 trial of human mesenchymal stem/stromal cells for the treatment of moderate-severe acute respiratory distress syndrome.

2014-07-0340 citations

Human mesenchymal stem cells reduce the severity of acute lung injury in a sheep model of bacterial pneumonia

Thorax2014-06-02181 citations

Treatment of acute respiratory distress syndrome with allogeneic adipose-derived mesenchymal stem cells: a randomized, placebo-controlled pilot study.

2014-04-04323 citations