all-trans retinoic acid (ATRA)

DRUG13 trials

Sponsors

University of Bergen, M.D. Anderson Cancer Center, Gruppo Italiano Malattie EMatologiche dell'Adulto, H. Lee Moffitt Cancer Center and Research Institute, Washington University School of Medicine

Conditions

APLAcute Myelogenous LeukemiaAcute Myeloid Leukemia (AML)Acute Promyelocytic LeukaemiaAcute Promyelocytic LeukemiaAcute Promyelocytic Leukemia (APL)Acute Promyelocytic Leukemia With PML-RARAAcute Promyelocytic Leukemia With t(15;17)(q24.1;q21.2); PML-RARA

Phase 1

Differentiation Induction in Acute Myelogenous Leukemia

CompletedNCT00175812

University of BergenAcute Myelogenous Leukemia

Start: 2004-11-30End: 2009-11-30Updated: 2015-06-24

Cladribine Based Induction Therapy With All-Trans Retinoic Acid and Midostaurin in Relapsed/Refractory AML

CompletedNCT01161550

Washington University School of MedicineLeukemia, Myeloid, Acute

Start: 2010-11-30End: 2012-08-31Updated: 2013-07-23

Revlimid / All-Trans Retinoic Acid (ATRA) / Dexamethasone in Relapsed/Refractory Multiple Myeloma

TerminatedNCT01985477

M.D. Anderson Cancer CenterMyeloma

Start: 2013-12-31End: 2015-09-30Updated: 2016-09-14

An Open-Label, Dose-Escalation/Dose-Expansion Safety Study of INCB059872 in Subjects With Advanced Malignancies

TerminatedNCT02712905

Incyte CorporationSolid Tumors and Hematologic Malignancy

Start: 2016-05-05End: 2022-04-14Updated: 2025-11-04

Daratumumab in Combination With ATRA

CompletedNCT02751255

Amsterdam UMC, location VUmcMultiple Myeloma

Start: 2016-07-06End: 2022-10-18Updated: 2023-04-28

Phase 2

Phase II 5-Azacytidine Plus VPA Plus ATRA

CompletedNCT00326170

M.D. Anderson Cancer CenterAcute Myelogenous Leukemia, Myelodysplastic Syndrome

Start: 2005-07-31End: 2007-12-31Updated: 2012-06-15

All-trans Retinoic Acid, and Arsenic +/- Idarubicin

CompletedNCT00413166

M.D. Anderson Cancer CenterAcute Promyelocytic Leukemia

Start: 2006-12-31End: 2016-02-29Updated: 2019-05-07

Vaccine Therapy, Tretinoin, and Cyclophosphamide in Treating Patients With Metastatic Lung Cancer

CompletedNCT00601796

H. Lee Moffitt Cancer Center and Research InstituteLung Cancer

Start: 2006-10-31End: 2012-06-30Updated: 2013-05-24

AIDA 2000 Guidelines

Gruppo Italiano Malattie EMatologiche dell'AdultoAcute Promyelocytic Leukemia

Start: 2000-05-31Target: 600Updated: 2020-10-14

Phase 3

Phase III Trial in Acute Promyelocytic Leukemia Patients

CompletedNCT00482833

Gruppo Italiano Malattie EMatologiche dell'AdultoLeukemia

Start: 2007-08-31End: 2019-10-17Updated: 2022-10-12

Study of Low-Dose Cytarabine and Etoposide With or Without All-Trans Retinoic Acid in Older Patients Not Eligible for Intensive Chemotherapy With Acute Myeloid Leukemia and NPM1 Mutation

CompletedNCT01237808

University of UlmAcute Myeloid Leukemia (AML)

Start: 2011-03-31End: 2018-07-13Updated: 2018-08-01

A Trial to Investigate Whether Oral Arsenic Trioxide Is Similar to Intravenous Arsenic Trioxide in Pharmacokinetics, Safety, and Efficacy (LATITUDE/SDKARS-301)

Not yet recruitingNCT07296445

SDK Therapeutics, Inc.Acute Promyelocytic Leukaemia, Acute Promyelocytic Leukemia, Acute Promyelocytic Leukemia (APL) +6

Start: 2026-01-31End: 2029-01-31Target: 120Updated: 2025-12-29

Unknown Phase

AIDA Protocol (LAP 0493)

Gruppo Italiano Malattie EMatologiche dell'AdultoLeukemia

Start: 1993-10-31End: 2020-12-31Target: 1068Updated: 2020-10-14

Related Papers

NK Cell Phenotype Is Associated With Response and Resistance to Daratumumab in Relapsed/Refractory Multiple Myeloma

HemaSphere2023-05-0132 citations

Immune Profiling of Multiple Myeloma Patients Treated with Daratumumab Monotherapy: Acquired and Primary Daratumumab-Resistance Is Associated with NK Cell Exhaustion

Blood2021-11-05

Efficacy and safety of daratumumab combined with all-<i>trans</i>retinoic acid in relapsed/refractory multiple myeloma

Blood Advances2021-10-0940 citations

Efficacy and Safety of Daratumumab Combined with All-Trans Retinoic Acid in Relapsed/Refractory Multiple Myeloma; Results of the Phase 1/2 Dara/ATRA Study

Blood2019-11-137 citations

Disease-stabilizing treatment based on all-trans retinoic acid and valproic acid in acute myeloid leukemia - identification of responders by gene expression profiling of pretreatment leukemic cells.

2017-09-0620 citations

Qualitative and Quantitative Correlation of PML-Rara Fusion Transcript from Peripheral Blood and Bone Marrow Samples By Quantitative Real-Time PCR in Patients with Acute Promyelocytic Leukemia

Blood2015-12-032 citations

Long Term Outcome of Patients with Acute Promyelocytic Leukemia Treated with All-Trans Retinoic Acid, Arsenic Trioxide with or without Gemtuzumab Ozogamicin

Blood2015-12-03

Cost-Effectiveness Analysis of Arsenic Trioxide in Combination with All-Trans Retinoic Acid in Acute Promyelocytic Leukemia with Pretreatment White Blood Counts <10G/L

Blood2014-12-06

Retinoic Acid and Arsenic Trioxide for Acute Promyelocytic Leukemia

New England Journal of Medicine2013-07-101571 citations

Specific cellular signal-transduction responses to in vivo combination therapy with ATRA, valproic acid and theophylline in acute myeloid leukemia.

2011-02-1121 citations

In vivo biological effects of ATRA in the treatment of AML.

2008-11-0132 citations